Pereira J B, Willcox H P, Coura J R
Mem Inst Oswaldo Cruz. 1985 Jan-Mar;80(1):63-71. doi: 10.1590/s0074-02761985000100010.
In a clinical, radiological and electrocardiographical, follow-up study of the "case control" type performed in Virgem da Lapa, Minas Gerais State, Brazil, 124 chagasic patients were followed during six years. The results of the patients, the majority in the indeterminate form, did not register any change, in 32.2% there was a progress in the disease and in 5.6% the electrocardiogram returned to normal. These results when compared to that achieved by the control group, composed of pairs of non chagasic persons with the same age and sex, was shown to be 27.4% higher than among patients with positive serology. This factor represents the excess risk or exclusively chagasic component in the development of the disease. No differences were observed by sex related to the development of the disease. It was more premature and seven times more frequent however when related to the cardiopathy than to the megaesophagus. Both conditions occurring mainly in slight or moderate degree. In 192 chagasic patients and 188 non chagasic persons observed in that area in the same period, the mortality was 3.6 times higher among the chagasic patients with a letality due to cardiopathy of 8.9% without difference between sexes but more premature among the males. Sudden death was more frequent than that one caused by cardiac insufficiency. The prognostic was good for the patients with indeterminate and digestive forms and reserved for patients with the highest degree of cardiopathy.
在巴西米纳斯吉拉斯州维珍达拉帕进行的一项“病例对照”类型的临床、放射学和心电图随访研究中，对124名恰加斯病患者进行了为期六年的随访。大多数患者处于不确定形式，结果显示病情无变化，32.2%的患者病情进展，5.6%的患者心电图恢复正常。与由年龄和性别相同的非恰加斯病患者组成的对照组相比，这些结果显示比血清学阳性患者高出27.4%。这个因素代表了疾病发展中的额外风险或恰加斯病的独有成分。在疾病发展方面未观察到性别差异。然而，与心肌病相关时比与巨食管相关时发病更早且频率高七倍。两种情况主要以轻度或中度出现。在同一时期该地区观察的192名恰加斯病患者和188名非恰加斯病患者中，恰加斯病患者的死亡率高出3.6倍，因心肌病导致的死亡率为8.9%，性别之间无差异，但男性发病更早。猝死比心脏功能不全导致的死亡更频繁。不确定型和消化型患者的预后良好，而心肌病程度最高的患者预后不佳。
