Pereira J B, Wilcox H P, Coura J R
Instituto Oswaldo Cruz/FIOCRUZ, Rio de Janeiro, Brasil.
Rev Soc Bras Med Trop. 1992 Apr-Jun;25(2):101-8. doi: 10.1590/s0037-86821992000200003.
During eight years (1982-1990) the evolution of chronic chagasic cardiopathy and its relation to parasitemia was evaluated in 279 patients, 85 men and 194 women, studied by resting electrocardiography and xenodiagnosis. All patients were residents in Virgem da Lapa, State of Minas Gerais, Brazil and their ages varied from 7 to 76 years (average 42.6 y). According to the results of the electrocardiograms the evolution of chagasic cardiopathy was classified as a) unchanged--when there was no change of the initial pattern off the ECG, b) progressive--when there was deterioration of the ECG pattern and c) regressive-when there was normalization or regression of the ECG alterations. Regarding xenodiagnosis 120 were considered with positive parasitemia, one or more xenodiagnoses positive, and 159 with negative parasitemia--all xenodiagnoses negative. The results showed: a) chagasic cardiopathy unchanged in 172 (61.6%) patients, b) progressive in 99 (35.5%) patients and c) regressive in 8 (2.9%). There was no relation between the evolution of chagasic cardiopathy and parasitemia. Independent from parasitemia, the cardiopathy was progressive according to the age of the patients and significantly greater in males. In conclusion we can state that evolution of chronic chagasic cardiopathy is associated with the age and with the male sex, but not with parasitemia, and this may suggest that parasitemia is not related to the development of the chronic chagasic cardiopathy.
在八年时间（1982 - 1990年）里，对279例患者的慢性恰加斯病性心脏病的演变及其与寄生虫血症的关系进行了评估，其中男性85例，女性194例，通过静息心电图和异种诊断进行研究。所有患者均为巴西米纳斯吉拉斯州维珍达拉帕的居民，年龄在7岁至76岁之间（平均42.6岁）。根据心电图结果，恰加斯病性心脏病的演变分为：a）无变化——心电图初始模式无改变；b）进展性——心电图模式恶化；c）退行性——心电图改变恢复正常或减轻。关于异种诊断，120例被认为寄生虫血症阳性，即一次或多次异种诊断呈阳性，159例寄生虫血症阴性——所有异种诊断均为阴性。结果显示：a）172例（61.6%）患者的恰加斯病性心脏病无变化；b）99例（35.5%）患者进展性；c）8例（2.9%）患者退行性。恰加斯病性心脏病的演变与寄生虫血症之间无关联。与寄生虫血症无关，心脏病根据患者年龄呈进展性，且男性更为显著。总之，我们可以说慢性恰加斯病性心脏病的演变与年龄和男性性别有关，但与寄生虫血症无关，这可能表明寄生虫血症与慢性恰加斯病性心脏病的发展无关。
