Programa em Doenças Infecciosas, Centro de Doenças Infecciosas, Universidade Federal do Espírito Santo, Vitoria, ES, Brazil.
Laboratório de Biologia Molecular de Parasitas e Fungos, Centro de Parasitologia e Micologia Instituto Adolfo Lutz, São Paulo, SP, Brazil.
Curr Top Membr. 2024;94:133-155. doi: 10.1016/bs.ctm.2024.06.003. Epub 2024 Aug 29.
Toxoplasma gondii, the causative agent of toxoplasmosis, is widely distributed. This protozoan parasite is one of the best adapted, being able to infect innumerous species of animals and different types of cells. This chapter reviews current literature on extracellular vesicles secreted by T. gondii and by its hosts. The topics describe the life cycle and transmission (1); toxoplasmosis epidemiology (2); laboratorial diagnosis approach (3); The T. gondii interaction with extracellular vesicles and miRNAs (4); and the perspectives on T. gondii infection. Each topic emphases the host immune responses to the parasite antigens and the interaction with the extracellular vesicles and miRNAs.
刚地弓形虫，即弓形体病的病原体，分布广泛。这种原生动物寄生虫是适应能力最强的寄生虫之一，能够感染无数种动物和不同类型的细胞。本章综述了刚地弓形虫及其宿主分泌的细胞外囊泡的最新文献。各主题分别描述了（1）生活史和传播；（2）弓形体病流行病学；（3）实验室诊断方法；（4）刚地弓形虫与细胞外囊泡和 microRNA 的相互作用；以及（5）刚地弓形虫感染的展望。每个主题都强调了宿主对寄生虫抗原的免疫反应以及与细胞外囊泡和 microRNA 的相互作用。
