Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Laboratory Medicine, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
J Med Virol. 2024 Oct;96(10):e29957. doi: 10.1002/jmv.29957.
This study aimed to assess the impact of COVID-19 on the prevalence of adenovirus (AdV) infection in children. This study retrospectively analyzed the changes in the epidemiological and clinical features of AdV-associated respiratory infections in children in Hangzhou, China, between January 2019 and July 2024. A total of 771 316 samples were included in the study, and the positive rate was 6.10% (47 050/771 316). Among them, the positive rate of AdV infection was highest in 2019, reaching 11.29% (26 929/238 333), while the positive rates in the remaining years were between 2% and 9%. In terms of seasonal epidemic characteristics, the summer of 2019 was the peak of AdV incidence, with the positive rate peaking at around 16.95% (7275/45 268), followed by a gradual decline and a low-level epidemic in winter, with a positive rate of 8.79% (8094/92 060). However, during the period 2020-2024, the AdV epidemic season did not show any significant regularity. Gender analysis revealed that the positive rate of male patients was generally greater than that of female patients. In different age groups, the population susceptible to AdV changed before and after the epidemic. In the early and middle stages of the COVID-19 epidemic, the susceptible population was mainly 2-5 years old, whereas in the later stages of the epidemic, the susceptible population was 5-18 years old. In addition, the main clinical symptoms of AdV-positive children from 2019-2024 were respiratory tract symptoms and fever. In summary, the COVID-19 epidemic has had a certain impact on the prevalence of AdV. These findings provide an important basis and reference for the prevention and diagnosis of AdV, especially in the context of increasing age- and gender-specific public health strategies.
本研究旨在评估 COVID-19 对儿童腺病毒（AdV）感染流行率的影响。本研究回顾性分析了 2019 年 1 月至 2024 年 7 月期间中国杭州儿童腺病毒相关呼吸道感染的流行病学和临床特征变化。本研究共纳入 771316 例样本，阳性率为 6.10%（47050/771316）。其中，2019 年 AdV 感染阳性率最高，达 11.29%（26929/238333），其余年份的阳性率在 2%至 9%之间。在季节性流行特征方面，2019 年夏季为 AdV 发病高峰，阳性率峰值约为 16.95%（7275/45268），随后逐渐下降，冬季呈低水平流行，阳性率为 8.79%（8094/92060）。然而，2020-2024 年期间，AdV 流行季节没有明显规律。性别分析显示，男性患者的阳性率普遍高于女性患者。在不同年龄组中，AdV 易感人群在疫情前后发生了变化。在 COVID-19 疫情的早期和中期，易感人群主要为 2-5 岁，而在疫情后期，易感人群为 5-18 岁。此外，2019-2024 年 AdV 阳性患儿的主要临床症状为呼吸道症状和发热。综上所述，COVID-19 疫情对 AdV 流行率有一定影响。这些发现为 AdV 的预防和诊断提供了重要依据和参考，特别是在针对特定年龄和性别的公共卫生策略日益增加的背景下。
