Patel Vimal, Chavda Vishal
Department of Pharmaceutics, Anand Pharmacy College, Anand, Gujarat 388001, India.
Department of Pathology, Stanford School of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA.
Cancer Pathog Ther. 2023 Dec 2;2(4):256-267. doi: 10.1016/j.cpt.2023.11.006. eCollection 2024 Oct.
Surgical excision is an important part of the multimodal therapy strategy for patients with glioblastoma, a very aggressive and invasive brain tumor. While major advances in surgical methods and technology have been accomplished, numerous hurdles remain in the field of glioblastoma surgery. The purpose of this literature review is to offer a thorough overview of the current challenges in glioblastoma surgery. We reviewed the difficulties associated with tumor identification and visualization, resection extent, neurological function preservation, tumor margin evaluation, and inclusion of sophisticated imaging and navigation technology. Understanding and resolving these challenges is critical in order to improve surgical results and, ultimately, patient survival.
手术切除是胶质母细胞瘤患者多模式治疗策略的重要组成部分，胶质母细胞瘤是一种极具侵袭性的脑部肿瘤。虽然手术方法和技术已取得重大进展，但胶质母细胞瘤手术领域仍存在许多障碍。这篇文献综述的目的是全面概述胶质母细胞瘤手术当前面临的挑战。我们回顾了与肿瘤识别和可视化、切除范围、神经功能保留、肿瘤边缘评估以及复杂成像和导航技术应用相关的困难。理解并解决这些挑战对于改善手术效果以及最终提高患者生存率至关重要。
