一名晚期人类免疫缺陷病毒病患者的猴痘复发与特考韦瑞耐药性
Mpox Recurrence and Tecovirimat Resistance in a Patient With Advanced Human Immunodeficiency Virus Disease.
作者信息
Griffith David C, Fall Amary, Carter Mihaela, Traut Caroline C, Sop Joel, Hansoti Bhakti, Gebo Kelly A, Mostafa Heba H, Blankson Joel N
机构信息
Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
出版信息
Open Forum Infect Dis. 2024 Sep 23;11(10):ofae549. doi: 10.1093/ofid/ofae549. eCollection 2024 Oct.
We present a case of mpox recurrence in a transgender woman with AIDS. Her recurrent lesions required several courses of antiviral therapy over a 5-month period and her monkeypox viral genome was subsequently noted to have tecovirimat resistance mutations. Interestingly, she developed a robust orthopoxvirus-specific T-cell response.
我们报告了一例患有艾滋病的跨性别女性猴痘复发的病例。她的复发性皮损在5个月内需要接受多个疗程的抗病毒治疗，随后发现她的猴痘病毒基因组存在对特考韦瑞有抗性的突变。有趣的是，她产生了强烈的正痘病毒特异性T细胞反应。
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