School of Medical, Shenzhen University, Shenzhen, 518060, People's Republic of China.
Department of Stomatology, Shenzhen University General Hospital, Shenzhen, 518055, People's Republic of China.
Int J Nanomedicine. 2024 Oct 1;19:10065-10076. doi: 10.2147/IJN.S481498. eCollection 2024.
The present study intended to evaluate the effect of simvastatin-loaded nanomicelles (SVNs) on promoting new bone formation and reducing alveolar ridge resorption at the tooth extraction sites at the early healing of the extraction sockets.
SVNs were synthesized using a dialysis method. The rabbit tooth extraction model was established, SVNs and simvastatin (SV) were loaded on gelatin sponge and inserted into the extraction socket. CBCT scans were performed at 0, 2, and 4 weeks postoperatively to evaluate bone formation and alveolar ridge absorption in the extraction sockets. And all the animals were sacrificed and the mandibles were harvested. And HE staining and Masson staining were used for histological evaluation of the bone formation in the extraction sockets.
Radiographic evaluation showed that compared with the blank control group, at 2 and 4 weeks after extraction, SVNs increased the new bone density in the extraction sockets by 75.7% and 96.5%, and reduced the absorption rate of alveolar ridge length at the extraction sites by 60.8% and 49.1%, respectively. Histological evaluation showed that SVNs significantly improved the maturation of new bone tissue in the extraction sockets.
SVNs can significantly accelerate healing and effectively reduce the absorption of alveolar ridge at the extraction sites in the early stage of tooth extraction socket healing.
本研究旨在评估载辛伐他汀纳米胶束（SVNs）对促进拔牙窝早期愈合中新骨形成和减少牙槽嵴吸收的作用。
采用透析法合成 SVNs。建立兔牙拔除模型，将 SVNs 和辛伐他汀（SV）载入明胶海绵并插入拔牙窝。术后 0、2 和 4 周行 CBCT 扫描，评估拔牙窝内骨形成和牙槽嵴吸收情况。所有动物均被处死并取下颌骨。采用 HE 染色和 Masson 染色对拔牙窝内骨形成进行组织学评价。
影像学评价显示，与空白对照组相比，拔牙后 2 和 4 周，SVNs 分别使拔牙窝内新骨密度增加了 75.7%和 96.5%，使牙槽嵴吸收长度的吸收率降低了 60.8%和 49.1%。组织学评价显示，SVNs 可显著改善拔牙窝内新骨组织的成熟度。
SVNs 可显著加速愈合，并在拔牙窝愈合的早期有效减少牙槽嵴的吸收。
