Cui Na, Zhao Chen, Xue Jun-Lai, Zhu Xue-Wei
Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
Department of Traditional Chinese Medicine, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China.
World J Clin Cases. 2024 Oct 6;12(28):6165-6172. doi: 10.12998/wjcc.v12.i28.6165.
Tinnitus affects 10%-30% of the population. Recent evidence suggests that tinnitus is associated with spleen deficiency. However, compared with kidney deficiency-related tinnitus, less research has been conducted on the impact of spleen deficiency-related tinnitus.
To investigate the clinical efficacy of using Guipi Wan and dietary and lifestyle modification based on traditional Chinese medicine for treatment of patients with spleen and stomach deficiency-related tinnitus.
We enrolled 110 patients with spleen and stomach deficiency-related tinnitus who were distributed into treatment (58 cases) and control (52 cases) groups. Tinnitus severity, sleep quality and emotional state were assessed by questionnaires [Tinnitus Evaluation Questionnaire (TEQ); Pittsburgh Sleep Quality Index (PSQI); Depression-Anxiety-Stress Scale-21 (DASS-21)] that were used for analysis in the two groups during the initial and intervention and after. In the treatment group, patients were treated with oral administration of Guipi Wan and consulted for healthy dietary and lifestyle modification. In the control group, patients were only assessed and not treated.
At the end of the 6-months, TEQ scores decreased significantly in the treatment group ( = 0.021) but not in the Control group. Significant effects in the treatment group were noted for PSQI total score ( = 0.043) and several PSQI component scores in the treatment group ( < 0.05). After treatment, the DASS-21 scores were significantly reduced in the treatment group ( < 0.05).
Guipi Wan combined with dietary and lifestyle modification based on regulating the spleen and stomach can be considered core to the treatment of tinnitus related to spleen and stomach deficiency.
耳鸣影响10%-30%的人群。最近有证据表明耳鸣与脾虚有关。然而，与肾虚相关耳鸣相比，关于脾虚相关耳鸣影响的研究较少。
探讨归脾丸联合基于中医的饮食和生活方式调整对脾胃虚弱相关耳鸣患者的临床疗效。
我们纳入了110例脾胃虚弱相关耳鸣患者，分为治疗组（58例）和对照组（52例）。通过问卷[耳鸣评估问卷（TEQ）；匹兹堡睡眠质量指数（PSQI）；抑郁-焦虑-压力量表-21（DASS-21）]评估耳鸣严重程度、睡眠质量和情绪状态，在初始、干预期间和之后用于两组分析。治疗组患者口服归脾丸治疗，并接受健康饮食和生活方式调整咨询。对照组患者仅接受评估而不接受治疗。
6个月结束时，治疗组的TEQ评分显著下降（P=0.021），而对照组未下降。治疗组PSQI总分（P=0.043）及几个PSQI成分评分有显著效果（P<0.05）。治疗后，治疗组的DASS-21评分显著降低（P<0.05）。
归脾丸联合基于调理脾胃的饮食和生活方式调整可被视为治疗脾胃虚弱相关耳鸣的核心方法。
