Murzabekov Marat, Persson Åsa, Asker Christian, Kilbo Edlund Karl, Eriksson Charlotta, Jernberg Tomas, Molnar Peter, Oudin Anna, Pyko Andrei, Lindvall Jenny, Lõhmus Mare, Persson Waye Kerstin, Nilsson Sommar Johan, Stockfelt Leo, Spanne Mårten, Svartengren Magnus, Ögren Mikael, Pershagen Göran, Ljungman Petter
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Swedish Meteorological & Hydrological Institute, Norrköping, Sweden.
Environ Epidemiol. 2024 Oct 3;8(5):e344. doi: 10.1097/EE9.0000000000000344. eCollection 2024 Oct.
Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden.
In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects aged 50-65 years, recruited between 2013 and 2018, coronary atherosclerosis was measured based on computer tomography (CT) scans as coronary artery calcium score, segment involvement score (SIS), and non-calcified plaques (NCP) at enrollment. Based on modified Nordic model, road-traffic noise exposure was modeled for 2000, 2013, and 2018 with interpolation for intermediate years. We investigated the association between time-weighted long-term exposure to road-traffic noise (L) and the prevalence of atherosclerosis using ordinal logistic regression models adjusting for potential socioeconomic, behavioral, and environmental confounders, including air pollution.
No clear associations were found between road-traffic noise and coronary atherosclerosis. The odds ratio for coronary artery calcium score was 1.00 (95% confidence interval [CI] = 0.96, 1.04), SIS 0.99 (0.96, 1.03), and NCP 0.98 (0.90, 1.03) per interquartile range (9.4 dB L) for road-traffic noise exposure during 10 years before enrollment. No consistent associations were observed in site-specific analyses or using shorter exposure periods. Furthermore, exposure-response analyses revealed no clear trends, and there were no strong interactions between road-traffic noise and cardiovascular risk factors in relation to the atherosclerosis markers.
Long-term exposure to road-traffic noise was not linked to coronary atherosclerosis or calcification in relatively healthy, middle-aged populations in Sweden.
道路交通噪声可能会影响中风和心肌梗死等心血管事件的发生发展，但病因机制仍不清楚。本研究旨在评估瑞典长期道路交通噪声暴露与冠状动脉粥样硬化之间的关系。
在瑞典心肺生物图像研究（SCAPIS）队列中，纳入了2013年至2018年间招募的30154名年龄在50 - 65岁之间的受试者，在入组时基于计算机断层扫描（CT）测量冠状动脉粥样硬化情况，包括冠状动脉钙化评分、节段累及评分（SIS）和非钙化斑块（NCP）。基于改良的北欧模型，对2000年、2013年和2018年的道路交通噪声暴露进行建模，并对中间年份进行插值。我们使用有序逻辑回归模型，在调整了包括空气污染在内的潜在社会经济、行为和环境混杂因素后，研究了时间加权的长期道路交通噪声暴露（L）与动脉粥样硬化患病率之间的关联。
未发现道路交通噪声与冠状动脉粥样硬化之间存在明确关联。在入组前10年，道路交通噪声暴露每增加一个四分位数间距（9.4 dB L），冠状动脉钙化评分的比值比为1.00（95%置信区间[CI] = 0.96, 1.04），SIS为0.99（0.96, 1.03），NCP为0.98（0.90, 1.03）。在特定部位分析或使用较短暴露期时，未观察到一致的关联。此外，暴露 - 反应分析未显示出明确趋势，并且在与动脉粥样硬化标志物相关的方面，道路交通噪声与心血管危险因素之间没有强烈的相互作用。
在瑞典相对健康的中年人群中，长期暴露于道路交通噪声与冠状动脉粥样硬化或钙化无关。
