Bhandare Saurabh Dilip
Nashik Gramin Shikshan Prasarak Mandal's, College of Pharmacy, Bramha Valley Educational Campus, (Lit. trans. in English, 'The college of pharmacy, campus for the rural and the village development; Bramha Valley Educational campus, Nashik'.). At, Anjaneri, Trambak, Nashik 422213. Maharashtra, India.
Toxicol Res (Camb). 2024 Oct 3;13(5):tfae160. doi: 10.1093/toxres/tfae160. eCollection 2024 Oct.
This study examines the therapeutic potential and toxicological profiles of species based on recent pharmacological investigations: "a therapeutic potential vs. toxicological risks of species: a pharmacological-toxicology dilemma." The study encompasses diverse research areas, including the mitigation of Bisphenol A (BPA)-induced ovarian damage using flavonoids (CCFs), acute and sub-acute toxicity assessments of water extract (CLW), and observations on toxicity in horses. In addition, this scientific study discusses the interplant communication dynamics between soybean and the parasitic dodder () under nutrient deficiency conditions. Key significant findings highlight the efficacy of CCFs in alleviating BPA-induced ovarian damage, the safety profile of CLW within specified doses, and clinical manifestations of toxicity in horses. Moreover, insights into interplant communication mechanisms emphasise the significance of protein-mediated interactions in nutrient-deficient environments. The report illustrates the potential toxicity of Dodder in humans, and further research findings into its chemical composition and toxicological profiles reveal great data on its phytotoxicity. Greater awareness and understanding of the risks associated with consuming Dodder and other similar plant species are crucial for preventing plant intoxication and have been a significant major focus of the present toxicology study of species. Hence, by addressing these objectives, the scientific study aims to balance the therapeutic benefits of Cuscuta species with their potential toxicological risks, contributing to a more nuanced understanding of their role in pharmacology and toxicology. This dual focus is crucial for guiding future research and informing safe usage practices.
本研究基于近期的药理学研究，考察了[菟丝子属]物种的治疗潜力和毒理学特征：“[菟丝子属]物种的治疗潜力与毒理学风险：药理学 - 毒理学困境”。该研究涵盖了多个不同的研究领域，包括使用[菟丝子属]类黄酮（CCFs）减轻双酚A（BPA）诱导的卵巢损伤、[菟丝子属]水提取物（CLW）的急性和亚急性毒性评估以及对马匹中[菟丝子属]毒性的观察。此外，这项科学研究还讨论了营养缺乏条件下大豆与寄生菟丝子（[菟丝子属]）之间的植物间通讯动态。关键的重要发现突出了CCFs在减轻BPA诱导的卵巢损伤方面的功效、CLW在特定剂量范围内的安全性概况以及马匹中[菟丝子属]毒性的临床表现。此外，对植物间通讯机制的见解强调了蛋白质介导的相互作用在营养缺乏环境中的重要性。该报告阐述了菟丝子对人类的潜在毒性，对其化学成分和毒理学特征的进一步研究结果揭示了大量关于其植物毒性的数据。提高对食用菟丝子和其他类似植物物种相关风险的认识和理解对于预防植物中毒至关重要，并且一直是当前对[菟丝子属]物种毒理学研究的一个重要主要焦点。因此，通过实现这些目标，这项科学研究旨在平衡菟丝子属物种的治疗益处与其潜在的毒理学风险，有助于更细致入微地理解它们在药理学和毒理学中的作用。这种双重关注对于指导未来研究和告知安全使用实践至关重要。
