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光生物调节与局部药物递送作为非手术牙周治疗辅助手段在牙周袋管理中的有效性:一例报告

Effectiveness of Photobiomodulation Versus Local Drug Delivery as an Adjunct to Non-surgical Periodontal Therapy in the Management of Periodontal Pockets: A Case Report.

作者信息

Rana Anju, Palwankar Pooja, Gopal Lipika

机构信息

Periodontology, Manav Rachna Dental College, School of Dental Sciences, Manav Rachna International Institute of Research and Studies (MRIIRS), Faridabad, IND.

出版信息

Cureus. 2024 Sep 5;16(9):e68719. doi: 10.7759/cureus.68719. eCollection 2024 Sep.

DOI:10.7759/cureus.68719
PMID:39371876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11453165/
Abstract

Periodontitis, a bacterial infection leading to the destruction of tooth-supporting tissues, is primarily driven by elevated levels of subgingival microorganisms. Effective periodontal therapy aims to eliminate or reduce these pathogens to halt disease progression, prevent recurrence, and regenerate lost tissues. This case report evaluates the effectiveness of non-surgical therapies, specifically tetracycline fibers and photobiomodulation therapy (PBMT), as adjuncts to scaling and root planing (SRP) in the treatment of periodontal disease using a split-mouth design. Mechanical SRP alone may not fully remove pathogens from deep periodontal pockets, potentially leading to disease recurrence. To address this, various other techniques have been explored, including the use of tetracycline fibers and PBMT. Local delivery methods aim to minimize systemic side effects while maintaining high antimicrobial concentrations in the gingival crevicular fluid, whereas PBMT, known for its anti-inflammatory and regenerative properties, involves exposing tissues to low-intensity light with wavelengths from red to near-infrared. This therapy activates cellular functions and mitochondrial processes, resulting in increased adenosine triphosphate (ATP) production, nitric oxide levels, and overall tissue healing. Tetracycline fibers have been highlighted for their effectiveness in periodontal therapy due to their localized antimicrobial action. The integration of tetracycline fibers and PBMT with SRP presents a promising non-surgical approach to enhance the management of periodontal disease. The case report aims to provide insights into the efficacy of these adjunctive therapies in improving clinical outcomes for patients with periodontitis.

摘要

牙周炎是一种导致牙齿支持组织破坏的细菌感染,主要由龈下微生物水平升高引起。有效的牙周治疗旨在消除或减少这些病原体,以阻止疾病进展、预防复发并使丧失的组织再生。本病例报告采用分口设计,评估非手术治疗,特别是四环素纤维和光生物调节疗法(PBMT)作为龈上洁治和根面平整(SRP)辅助手段在牙周病治疗中的有效性。单独的机械性SRP可能无法完全清除深部牙周袋中的病原体,从而可能导致疾病复发。为解决这一问题,人们探索了各种其他技术,包括使用四环素纤维和PBMT。局部给药方法旨在将全身副作用降至最低,同时在龈沟液中保持高抗菌浓度,而以其抗炎和再生特性闻名的PBMT则是将组织暴露于波长从红色到近红外的低强度光下。这种疗法激活细胞功能和线粒体过程,导致三磷酸腺苷(ATP)生成增加、一氧化氮水平升高以及整体组织愈合。四环素纤维因其局部抗菌作用在牙周治疗中的有效性而受到关注。四环素纤维和PBMT与SRP相结合,为加强牙周病管理提供了一种有前景的非手术方法。该病例报告旨在深入了解这些辅助疗法在改善牙周炎患者临床结局方面的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/4f96728b0ce4/cureus-0016-00000068719-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/05e514fe276c/cureus-0016-00000068719-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/477deb4b39d6/cureus-0016-00000068719-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/037c23398866/cureus-0016-00000068719-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/b7dc81986df8/cureus-0016-00000068719-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/73c957e9d24e/cureus-0016-00000068719-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/d41b18330f63/cureus-0016-00000068719-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/a77b80078f29/cureus-0016-00000068719-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/14f5d17fd7b2/cureus-0016-00000068719-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/4f96728b0ce4/cureus-0016-00000068719-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/05e514fe276c/cureus-0016-00000068719-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/477deb4b39d6/cureus-0016-00000068719-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/037c23398866/cureus-0016-00000068719-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/b7dc81986df8/cureus-0016-00000068719-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/73c957e9d24e/cureus-0016-00000068719-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/d41b18330f63/cureus-0016-00000068719-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/a77b80078f29/cureus-0016-00000068719-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/14f5d17fd7b2/cureus-0016-00000068719-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e57e/11453165/4f96728b0ce4/cureus-0016-00000068719-i09.jpg

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Diabetes in spotlight: current knowledge and perspectives of photobiomodulation utilization.糖尿病聚焦:光生物调节利用的当前知识和观点。
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