Khan Allah Yar Yahya, Khalid Rana Muhammad Asadullah, Mehmood Qadri Haseeb, Amir Arham
General Surgery, Akhtar Saeed Medical and Dental College, Lahore, PAK.
General Surgery, Aziz Fatimah Medical and Dental College, Faisalabad, PAK.
Cureus. 2024 Sep 5;16(9):e68697. doi: 10.7759/cureus.68697. eCollection 2024 Sep.
The ketogenic diet (KD) has gained a lot of attraction in the management of neurological disorders. KD therapies are high-fat, low-carbohydrate diets intended to shift energy consumption and metabolism from carbohydrates to fat in ketogenesis. The oxidative phosphorylation of ketone bodies generates energy packets for body cells, especially the central nervous system, replacing the role of glucose. KD can benefit multiple neurologic disorders like migraine, motor neuron disease, autism, multiple sclerosis, neuro-oncology, drug-resistant epilepsy, and neurotrauma. KD can provide significant adjuncts to limited conventional therapies, highlighting the feasibility, safety, and potential efficacy in neurology and neurosurgical disease management.
生酮饮食(KD)在神经系统疾病的治疗中备受关注。KD疗法是高脂肪、低碳水化合物饮食,旨在使能量消耗和代谢从碳水化合物转变为酮生成中的脂肪。酮体的氧化磷酸化为身体细胞(尤其是中枢神经系统)产生能量包,取代葡萄糖的作用。KD可使多种神经系统疾病受益,如偏头痛、运动神经元病、自闭症、多发性硬化症、神经肿瘤学、耐药性癫痫和神经创伤。KD可为有限的传统疗法提供重要辅助,凸显了其在神经病学和神经外科疾病管理中的可行性、安全性及潜在疗效。