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下颌骨中伴发单纯性骨囊肿的 florid 骨化纤维瘤的临床、CBCT 及组织学分析:一例报告

Clinical, CBCT and Histological Analysis of a Florid Cemento-Osseous Dysplasia with Co-Occurrence of Simple Bone Cyst in the Mandible: A Case Report.

作者信息

Berberi Antoine

机构信息

Director Research Center, Faculty of Dental Medicine, Lebanon University, Beirut, Lebanon.

出版信息

J Dent (Shiraz). 2024 Sep 1;25(3):278-287. doi: 10.30476/dentjods.2024.101163.2276. eCollection 2024 Sep.

Abstract

Cemento-osseous dysplasia (COD) is classified, by the World Health Organization as a benign fibro-osseous lesion related to the tooth and periapical area of the jaws and is considered as a benign reactive process appearing from the apical periodontium in close relation with the apices of teeth. Usually, it is asymptomatic, discovered accidentally, and affecting particularly middle-aged African women. There are four subtypes distinguished of the lesion: periapical (PCOD), focal (FCOD), florid (FLCOD) and familial florid cemento-osseous dysplasia (FFLCOD). Pseudocysts found in the jaws go by various names, including solitary bone cyst, traumatic bone cyst, or simple bone cyst (SBC). These two pathologies have been reported separately; however, their co-occurrence remains rare and the first case of FLCOD with co-occurrence of SBC was reported by Melrose . in 1976 and later a few cases been reported in the literature. The aim of this report is to describe a case of a 46-year-old oriental female diagnosed with FLCOD with co-occurrence of SBC. Under local analgesia, a surgical exploration of the cyst was performed. In addition, a biopsy with a trephine was done in the region of missing right first mandibular molar. Based on the patient clinical, radiographic, and histological findings, a diagnosis of FLCOD was made in co-occurrence with a mandibular SBC. An examination of another female family member unveils a distinctive case, and the familial factor has been ruled out. No further treatment was planned and only follow-up was suggested.

摘要

骨化性纤维瘤(COD)被世界卫生组织归类为一种与牙齿及颌骨根尖区相关的良性纤维-骨病变,被认为是一种从根尖牙周膜出现的、与牙根尖密切相关的良性反应性过程。通常,它无症状,多为偶然发现,尤其好发于中年非洲女性。该病变有四种不同的亚型:根尖周型(PCOD)、局灶型(FCOD)、 florid型(FLCOD)和家族性 florid骨化性纤维瘤(FFLCOD)。颌骨中发现的假性囊肿有多种名称,包括孤立性骨囊肿、创伤性骨囊肿或单纯性骨囊肿(SBC)。这两种病理情况曾分别有报道;然而,它们同时出现的情况仍然罕见,首例FLCOD合并SBC的病例由梅尔罗斯于1976年报道,之后文献中又报道了几例。本报告的目的是描述一例46岁东方女性被诊断为FLCOD合并SBC的病例。在局部麻醉下,对囊肿进行了手术探查。此外,在右下第一磨牙缺失区域进行了环钻活检。根据患者的临床、影像学和组织学检查结果,诊断为FLCOD合并下颌SBC。对另一名女性家庭成员的检查发现了一个独特的病例,排除了家族因素。未计划进一步治疗,仅建议进行随访。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1330/11452594/5e28723b3379/JDS-25-278-g001.jpg

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