Elson Edward C
Division of Neuropsychiatry, Microwave Bioeffects and Hazards Laboratory, Walter Reed Army Institute of Research, Bethesda, Maryland, USA.
Bioelectricity. 2024 Sep 16;6(3):196-203. doi: 10.1089/bioe.2023.0050. eCollection 2024 Sep.
Despite the elucidation of the many processes by which a single eukaryotic cell develops into a complex mature organism, it is still puzzling to some biologists how it is that an unvarying, interconnected set of processes becomes coordinated and insulated from a stochastic universe. This article suggests that electromagnetic processes deriving from the chemistry of an organism may provide such coordination. Specifically, the author develops the pacemaker concept, the periodic, autonomous electrical signal to the entire embryo, the result of which, after each pulse, is to alter or enlarge the transcriptome to produce the next level of complexity and maturity of the organism.
尽管已经阐明了单个真核细胞发育成复杂成熟生物体的许多过程,但对一些生物学家来说,一组不变且相互关联的过程如何变得协调并与随机的宇宙隔离开来,仍然令人困惑。本文认为,源自生物体化学过程的电磁过程可能提供这种协调。具体而言,作者提出了起搏器概念,即向整个胚胎发送周期性、自主性电信号,每次脉冲的结果是改变或扩大转录组,以产生生物体下一个层次的复杂性和成熟度。