Yılmaz Dilara, Singh Amit, Wehrle Esther, Kuhn Gisela A, Mathavan Neashan, Müller Ralph
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland.
AO Research Institute Davos, Davos, Davos Platz, Switzerland.
Front Aging. 2024 Sep 20;5:1365716. doi: 10.3389/fragi.2024.1365716. eCollection 2024.
Frailty, a geriatric syndrome, is assessed using the frailty phenotype (FP) and frailty index (FI). While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA (PolgA) has not been completely explored. We demonstrated that frailty became evident in PolgA mice around 40 weeks, validated through body weight loss, reduced walking speed, decreased physical activity, and weaker grip strength. Moreover, we also identified sex differences in these mice with females exhibiting slightly more physical decline compared to males. Frailty prevalence in PolgA mice at 40 weeks parallels that observed in naturally aging mice at 27 months and aging humans at 65-70 years. These findings contribute to understanding frailty onset and sex-specific patterns in this prematurely aging mouse model, emphasizing the significance of the PolgA mouse model in investigating aging and related disorders.
衰弱是一种老年综合征，可通过衰弱表型（FP）和衰弱指数（FI）进行评估。虽然这些方法已应用于衰老小鼠，但它们在诸如PolgA（PolgA）等早衰小鼠模型中的有效性尚未得到充分探索。我们证明，衰弱在约40周龄的PolgA小鼠中变得明显，通过体重减轻、步行速度降低、身体活动减少和握力减弱得以验证。此外，我们还发现这些小鼠存在性别差异，雌性小鼠的身体衰退比雄性小鼠略多。40周龄PolgA小鼠的衰弱患病率与27个月龄自然衰老小鼠以及65 - 70岁老年人中观察到的患病率相当。这些发现有助于理解这种早衰小鼠模型中衰弱的发生及性别特异性模式，强调了PolgA小鼠模型在研究衰老及相关疾病中的重要性。
