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颅内感染罕见病例：凸显下一代测序技术在诊断中的应用价值

A Rare Case of Intracranial Infection: Highlighting the Utility of Next-Generation Sequencing in Diagnosis.

作者信息

Whitman Melissa, Vissichelli Nicole

机构信息

Division of Infectious Diseases Virginia Commonwealth University Health System, Richmond, Virginia 23298-0049, USA.

出版信息

Case Rep Transplant. 2024 Sep 28;2024:8892177. doi: 10.1155/2024/8892177. eCollection 2024.

DOI:10.1155/2024/8892177
PMID:39372424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11455592/
Abstract

is a dematiaceous fungi and the most common cause of cerebral phaeohyphomycosis. Here, we report a rare case of cerebral ventriculitis with development of a cerebral abscess due to diagnosed by cell-free DNA next-generation sequencing. Noninvasive diagnostics led to earlier disease identification and initiation of antifungal therapy, which has the potential to reduce mortality in this highly fatal disease.

摘要

是一种暗色真菌，也是脑暗色丝孢霉病最常见的病因。在此，我们报告一例罕见的脑室炎病例，该病例因通过游离DNA下一代测序诊断出 而并发脑脓肿。非侵入性诊断导致更早地识别疾病并启动抗真菌治疗，这有可能降低这种高致死性疾病的死亡率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/11455592/0a2d71118c55/CRIT2024-8892177.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/11455592/0a2d71118c55/CRIT2024-8892177.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa16/11455592/0a2d71118c55/CRIT2024-8892177.001.jpg

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本文引用的文献

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Serial Quantitation of Plasma Microbial Cell-Free DNA Before and After Diagnosis of Pulmonary Invasive Mold Infections After Hematopoietic Cell Transplant.造血细胞移植后肺侵袭性霉菌感染诊断前后血浆微生物游离DNA的连续定量分析
J Infect Dis. 2024 Feb 14;229(2):576-587. doi: 10.1093/infdis/jiad255.
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Metagenomics next-generation sequencing for the diagnosis of central nervous system infection: A systematic review and meta-analysis.宏基因组学下一代测序技术在中枢神经系统感染诊断中的应用：一项系统评价和荟萃分析
Front Neurol. 2022 Sep 20;13:989280. doi: 10.3389/fneur.2022.989280. eCollection 2022.
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Utility of liquid biopsy in diagnosing isolated cerebral phaeohyphomycosis: illustrative case.
液体活检在孤立性脑暗色丝孢霉病诊断中的应用：病例说明
J Neurosurg Case Lessons. 2022 Jan 31;3(5). doi: 10.3171/CASE21557.
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Management of Extensive Central Nervous System Cladophialophora bantiana Infection in a 9-Year-Old Child.9 岁儿童广泛中枢神经系统枝孢霉属感染的治疗。
Pediatr Infect Dis J. 2022 Nov 1;41(11):e481-e486. doi: 10.1097/INF.0000000000003680. Epub 2022 Aug 31.
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Aggressive disseminated Rhizomucor pusillus infection in a Ph-like acute lymphoblastic leukemia patient: Early detection by cell-free DNA next-generation sequencing.Ph 样急性淋巴细胞白血病患者侵袭性播散的少根根霉感染：通过游离 DNA 下一代测序的早期检测。
J Infect Chemother. 2022 Mar;28(3):459-464. doi: 10.1016/j.jiac.2021.12.007. Epub 2021 Dec 23.
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Surg J (N Y). 2017 Mar 30;3(2):e62-e68. doi: 10.1055/s-0037-1598248. eCollection 2017 Apr.
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