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由班替枝孢霉引起的脑暗色丝孢霉病——一例报告及来自印度的文献综述

Cerebral Phaeohyphomycosis due to Cladophialophora bantiana - A Case Report and Review of Literature from India.

作者信息

Suri Pooja, Chhina Deepinder Kaur, Kaushal Vandana, Kaushal Rakesh Kumar, Singh Jasdeep

机构信息

Assistant Professor, Department of Microbiology, Dayanand Medical College and Hospital , Ludhiana, India .

Professor and Head, Department of Microbiology, Dayanand Medical College and Hospital , Ludhiana, India .

出版信息

J Clin Diagn Res. 2014 Apr;8(4):DD01-5. doi: 10.7860/JCDR/2014/7444.4216. Epub 2014 Apr 15.

Abstract

Cerebral phaeohyphomycosis is a rare disease caused by dematiaceous fungi. It has poor prognosis irrespective of the immune status of the patient. Cladophialophora bantiana is the most commonly isolated species. We report a case of multiple brain abscesses caused by C. bantiana in an immune competent patient. The diagnosis was based on CT scan of head, direct examination and culture of the aspirate from the abscess. Despite complete surgical resection of the abscesses and antifungal therapy with amphotericin B and voriconazole the patient could not be saved. All the cases of cerebral phaeohyphomycosis due to this rare neurotropic fungus reported from India between 1962 and 2009 have also been reviewed.

摘要

脑暗色丝孢霉病是一种由暗色真菌引起的罕见疾病。无论患者的免疫状态如何,其预后都很差。班替枝孢霉是最常分离出的菌种。我们报告一例免疫功能正常的患者由班替枝孢霉引起的多发性脑脓肿病例。诊断基于头部CT扫描、脓肿抽吸物的直接检查和培养。尽管脓肿已完全手术切除,并使用两性霉素B和伏立康唑进行抗真菌治疗,但患者仍未能挽救生命。我们还回顾了1962年至2009年间印度报道的所有由这种罕见嗜神经真菌引起的脑暗色丝孢霉病病例。

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