Kantak Divya, Dsouza Marius
Department of Medicine, The Grant Government Medical College and Sir J.J. Group of Hospitals, JJ Marg, Nagpada-Mumbai Central, Near Sandhurst Road and J J Police Station, Mumbai, Maharashtra, India.
Indian J Nephrol. 2024 Sep-Oct;34(5):520-521. doi: 10.25259/ijn_536_23. Epub 2024 Jun 29.
Leprosy, an infectious disease known for its debilitating effects on the skin and nerves, can trigger immunologic reactions affecting multiple organs. We present the case of a 57-year-old male who developed acute glomerulonephritis following leprosy treatment. Clinical examination revealed newly developed pitting edema in the legs, along with residual nerve thickening and skin changes. Laboratory findings showed elevated serum creatinine (3.2mg/dl) accompanied by low C3 and C4 levels. Urinalysis supported the diagnosis of glomerulonephritis. Renal biopsy demonstrated immune complex deposition on immunofluorescence, suggesting a diagnosis of leprosy-related post-treatment immune-mediated glomerulonephritis. Treatment with oral steroids led to complete resolution of the condition.
麻风病是一种以对皮肤和神经造成衰弱性影响而闻名的传染病，可引发影响多个器官的免疫反应。我们报告一例57岁男性在麻风病治疗后发生急性肾小球肾炎的病例。临床检查发现双下肢新出现凹陷性水肿，伴有残留的神经粗大及皮肤改变。实验室检查结果显示血清肌酐升高（3.2mg/dl），同时C3和C4水平降低。尿液分析支持肾小球肾炎的诊断。肾活检免疫荧光显示免疫复合物沉积，提示诊断为麻风病相关治疗后免疫介导性肾小球肾炎。口服类固醇治疗使病情完全缓解。
