Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Aksum, Ethiopia.
Department of Statistics, College of Natural and Computational Sciences, Adigrat University, Adigrat, Ethiopia.
Pan Afr Med J. 2024 Sep 4;49:6. doi: 10.11604/pamj.2024.49.6.43263. eCollection 2024.
hepatitis is an inflammatory disease of the liver; it is a major threat to public health and is more prevalent worldwide. Hepatitis B virus (HBV) is the leading cause of cirrhosis and hepatocellular carcinoma (HCC) with increasing mortality and burden of disease particularly in Asia and sub-Saharan Africa. Therefore, this study intended to assess the prevalence of HBsAg, associated risk factors, and liver enzyme abnormalities among individuals with diabetes mellitus (DM) in Aksum town public hospitals, Tigray, northern Ethiopia.
a hospital-based cross-sectional study was conducted among 359 randomly selected individuals with diabetes mellitus in public hospitals of Aksum town from February 10 to May 10, 2021. A pre-tested structured questionnaire was used to collect the data. Data was entered into Epi-Data version 3.1 and analysis was made using the statistical software SPSS version 21 for Windows. Bivariate and multivariate Logistic regression model was applied to show association between the dependent and independent variables; P <0.05 and 95% confidence interval was considered for statistical significance.
in this study, 359 individuals with DM were included with a mean age (mean ± SD) of 46.44 ±16.58 years. The percentage of female participants was 44.3% (159/359). The prevalence of HBsAg among individuals with diabetes mellitus in Aksum town public hospitals was 12.8% (95% CI:8.9-17.0%). The associated risk factors were being employed [AOR:13.38, 95% CI 2.79-64.11; p<0.05], having history of multiple sexual partner [AOR:3.49, 95% CI 1.33-9.12; p<0.05], having history of body incision or piercing [AOR:3.80, 95% CI 1.12-12.90; p<0.05], liver enzyme abnormalities [AOR:6.90, 95% CI 2.17-21.94; p<0.005], and being single and widowed in marital status [AOR:4.42, 95% CI1.62-12.07; p<0.05].
based on the HBsAg positivity, the prevalence of HBV among individuals with diabetes mellitus in this study area was high, as compared to the national findings. Therefore, integrated efforts should be made at the community and health facility level to raise awareness of the associated risk factors, and reduce the spread of HBV; targeted screening of HBV among people with diabetes is also important to minimize liver abnormalities.
肝炎是肝脏的炎症性疾病；它是对公众健康的主要威胁，在全球范围内更为普遍。乙型肝炎病毒（HBV）是导致肝硬化和肝细胞癌（HCC）的主要原因，尤其是在亚洲和撒哈拉以南非洲，其死亡率和疾病负担不断增加。因此，本研究旨在评估埃塞俄比亚提格雷州阿克萨姆镇公立医院中糖尿病患者中 HBsAg 的流行率、相关危险因素和肝酶异常。
这是一项在 2021 年 2 月 10 日至 5 月 10 日期间在阿克萨姆镇公立医院进行的 359 名随机选择的糖尿病患者的基于医院的横断面研究。使用经过预测试的结构化问卷收集数据。数据输入 Epi-Data 版本 3.1，并使用 Windows 版统计软件 SPSS 版本 21 进行分析。应用双变量和多变量逻辑回归模型来显示依赖变量和独立变量之间的关联；P<0.05 和 95%置信区间被认为具有统计学意义。
在这项研究中，包括 359 名糖尿病患者，平均年龄（均值±标准差）为 46.44±16.58 岁。女性参与者的比例为 44.3%（159/359）。阿克萨姆镇公立医院中糖尿病患者的 HBsAg 流行率为 12.8%（95%CI：8.9-17.0%）。相关的危险因素包括就业（AOR：13.38，95%CI 2.79-64.11；p<0.05）、有多个性伴侣史（AOR：3.49，95%CI 1.33-9.12；p<0.05）、有身体切口或刺穿史（AOR：3.80，95%CI 1.12-12.90；p<0.05）、肝酶异常（AOR：6.90，95%CI 2.17-21.94；p<0.005）和单身和丧偶的婚姻状况（AOR：4.42，95%CI1.62-12.07；p<0.05）。
根据 HBsAg 阳性率，本研究地区糖尿病患者中 HBV 的流行率高于全国水平。因此，应在社区和卫生机构层面做出综合努力，提高对相关危险因素的认识，并减少 HBV 的传播；对糖尿病患者进行 HBV 的针对性筛查对于最小化肝脏异常也很重要。
