Balleisen L, Assmann G, Bailey J, Epping P H, Schulte H, van de Loo J
Thromb Haemost. 1985 Oct 30;54(3):721-3.
In a preceding paper the baseline data in the Münster Arteriosclerosis Study (PROCAM study) of the levels of fibrinogen, factor VIIc and factor VIIIc were described, and their correlation of age, body weight, smoking, alcohol, pill-using and menopause discussed. In this part the relationship of these coagulation factors to blood pressure, blood glucose, uric acid and lipid parameters, which were examined in 4186 apparently healthy individuals, is presented. The correlations are described using two different statistical models, first the Pearson correlation coefficients after allowing each clotting factor for the effects of age, cigarette and alcohol consumption, body weight, menopausal state, pill using and the other clotting factors, and secondly by a multiple regression analysis. The data suggest that there are multiple interrelationships between hemostatic factors and the variables under consideration. The most striking positive correlations were found for factor VIIc to blood glucose and triglycerides in men and women and to HDL-cholesterol in women.
在之前的一篇论文中，描述了明斯特动脉硬化研究（PROCAM研究）中纤维蛋白原、凝血因子VIIc和凝血因子VIIIc水平的基线数据，并讨论了它们与年龄、体重、吸烟、饮酒、使用避孕药和绝经的相关性。在这一部分中，呈现了这些凝血因子与在4186名看似健康的个体中检测的血压、血糖、尿酸和血脂参数之间的关系。使用两种不同的统计模型描述相关性，首先是在考虑每个凝血因子的年龄、吸烟和饮酒量、体重、绝经状态、使用避孕药情况以及其他凝血因子的影响后得出的皮尔逊相关系数，其次是通过多元回归分析。数据表明，止血因子与所考虑的变量之间存在多种相互关系。在男性和女性中，凝血因子VIIc与血糖和甘油三酯，以及在女性中与高密度脂蛋白胆固醇之间发现了最显著的正相关。
