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某工业人群中凝血因子VII、凝血因子VIII和纤维蛋白原的流行病学研究:I. 与年龄、性别、体重、吸烟、饮酒、服用避孕药及绝经相关的基线数据

Epidemiological study on factor VII, factor VIII and fibrinogen in an industrial population: I. Baseline data on the relation to age, gender, body-weight, smoking, alcohol, pill-using, and menopause.

作者信息

Balleisen L, Bailey J, Epping P H, Schulte H, van de Loo J

出版信息

Thromb Haemost. 1985 Aug 30;54(2):475-9.

PMID:3936217
Abstract

The Münster Arteriosclerosis Study (MAS) is a prospective, longitudinal epidemiological study on an industrial population in Westfalia aimed to establishing clinical and laboratory data with possible relationship to cardiovascular events. The data presented here describe the baseline measurements of fibrinogen, factor VIIc and factor VIIIc from the recruitment of 2880 male and 1306 female persons and their relationship to age, gender, bodyweight, smoking, alcohol, pill-using and menopause. The correlations were made by means of a multiple regression analysis. We found an increase of those coagulation factors with age, a correlation of F VII and fibrinogen with body-weight index and of fibrinogen with cigarette smoking. No correlation was found for alcohol consumption. F VIII and F VII were significantly higher after onset of menopause and F VII and fibrinogen in women using the pill.

摘要

明斯特动脉硬化研究(MAS)是一项针对威斯特伐利亚工业人口的前瞻性纵向流行病学研究,旨在建立与心血管事件可能相关的临床和实验室数据。此处呈现的数据描述了2880名男性和1306名女性招募时纤维蛋白原、凝血因子VIIc和凝血因子VIIIc的基线测量值,以及它们与年龄、性别、体重、吸烟、饮酒、使用避孕药和绝经的关系。相关性通过多元回归分析得出。我们发现这些凝血因子随年龄增加,凝血因子VII和纤维蛋白原与体重指数相关,纤维蛋白原与吸烟相关。未发现与饮酒相关。绝经后凝血因子VIII和凝血因子VII显著升高,使用避孕药的女性中凝血因子VII和纤维蛋白原升高。

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