Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education, School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Shandong Provincial Key Laboratory of Biomedical Polymers, Shandong Academy of Pharmaceutical Sciences, Jinan, Shandong 250100, China.
Biomater Sci. 2024 Oct 22;12(21):5468-5480. doi: 10.1039/d4bm00956h.
Injectable hydrogels, as a class of highly hydrated soft materials, are of interest for biomedicine due to their precise implantation and minimally invasive local drug delivery at the implantation site. The combination of gelation ability and versatile therapeutic agent/cell loading capabilities makes injectable hydrogels ideal materials for drug delivery, tissue engineering, wound dressing and tumor treatment. In particular, the stimuli-responsive injectable hydrogels that can respond to different stimuli in and out of the body (, temperature, pH, redox conditions, light, magnetic fields, .) have significant advantages in biomedicine. Here, we summarize the design strategies, advantages, and recent developments of stimuli-responsive injectable hydrogels in different biomedical fields. Challenges and future perspectives of stimuli-responsive injectable hydrogels are also discussed and the future steps necessary to fulfill the potential of these promising materials are highlighted.
可注射水凝胶作为一类高度水合的软物质，由于其在植入部位的精确植入和微创局部药物递送而引起了生物医学的关注。凝胶能力与多功能治疗剂/细胞负载能力的结合使可注射水凝胶成为药物递送、组织工程、伤口敷料和肿瘤治疗的理想材料。特别是，能够响应体内和体外不同刺激的（，温度、pH 值、氧化还原条件、光、磁场、）的响应性可注射水凝胶在生物医学中具有显著优势。在这里，我们总结了不同生物医学领域中响应性可注射水凝胶的设计策略、优点和最新进展。还讨论了响应性可注射水凝胶的挑战和未来展望，并强调了实现这些有前途的材料潜力所需的未来步骤。
