Center of Personalized Nanomedicine, Institute of NeuroImmune Pharmacology, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL-33199. United States.
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi 110029. India.
Curr Pharm Des. 2017;23(24):3595-3602. doi: 10.2174/1381612823666170516144914.
The emergence of injectable hydrogels as biomaterials has been a revolutionary breakthrough in the field of on-demand drug delivery and tissue engineering. The promising features of these systems include their biodegradability, biocompatibility, permeability, ease of the surgical implantation, and most importantly exhibit minimally invasiveness. These hydrogels have been explored as sustained and on-demand release carriers for the various bioactive agents, growth factors, live cells, various hydrophobic drugs and as extracellular matrices for tissue engineering. Present review is an attempt to highlight the recent systems explored for on-demand drug release and tissue engineering. It also gives an overview of the role of nanotechnology in the advancements of injectable hydrogels. The future prospects and challenges of these hydrogels have also been addressed.
作为生物材料的可注射水凝胶的出现是按需药物输送和组织工程领域的一项革命性突破。这些系统的有前途的特点包括其生物降解性、生物相容性、渗透性、易于手术植入,最重要的是表现出最小的侵入性。这些水凝胶已被探索用作各种生物活性剂、生长因子、活细胞、各种疏水性药物和作为组织工程的细胞外基质的持续和按需释放载体。本综述旨在强调最近探索用于按需药物释放和组织工程的系统。它还概述了纳米技术在可注射水凝胶发展中的作用。还讨论了这些水凝胶的未来前景和挑战。