Li Lvyuan, Zhang Yi, Tang Qiling, Wu Chunyu, Yang Mei, Hu Yan, Gong Zhaojian, Shi Lei, Guo Can, Zeng Zhaoyang, Chen Pan, Xiong Wei
NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medicine Sciences, Central South University, Changsha, Hunan, 410078, China.
Cell Oncol (Dordr). 2024 Dec;47(6):2031-2047. doi: 10.1007/s13402-024-01000-1. Epub 2024 Oct 7.
Mitochondria play a central role in cellular energy production and metabolic regulation, and their function has been identified as a key factor influencing tumor immune responses. This review provides a comprehensive overview of the latest advancements in understanding the role of mitochondria in tumor immune surveillance, covering both innate and adaptive immune responses. Specifically, it outlines how mitochondria influence the function of the tumor immune system, underscoring their crucial role in modulating immune cell behavior to either promote or inhibit tumor development and progression. Additionally, this review highlights emerging drug interventions targeting mitochondria, including novel small molecules with significant potential in cancer therapy. Through an in-depth analysis, it explores how these innovative strategies could improve the efficacy and outlook of tumor treatment.
线粒体在细胞能量产生和代谢调节中发挥核心作用，其功能已被确定为影响肿瘤免疫反应的关键因素。本综述全面概述了在理解线粒体在肿瘤免疫监视中的作用方面的最新进展，涵盖固有免疫和适应性免疫反应。具体而言，它概述了线粒体如何影响肿瘤免疫系统的功能，强调了它们在调节免疫细胞行为以促进或抑制肿瘤发展和进展方面的关键作用。此外，本综述突出了针对线粒体的新兴药物干预措施，包括在癌症治疗中具有巨大潜力的新型小分子。通过深入分析，探讨了这些创新策略如何提高肿瘤治疗的疗效和前景。
