Lai Yiling, Wang Sibao
CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing, China.
New Cornerstone Science Laboratory, CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai, China; email:
Annu Rev Entomol. 2025 Jan;70(1):293-311. doi: 10.1146/annurev-ento-022724-010640. Epub 2024 Dec 19.
Insects have evolved diverse interactions with a variety of microbes, such as pathogenic fungi, bacteria, and viruses. The immune responses of insect hosts, along with the dynamic infection process of microbes in response to the changing host environment and defenses, require rapid and fine-tuned regulation of gene expression programs. Epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding RNA regulation, play important roles in regulating the expression of genes involved in insect immunity and microbial pathogenicity. This review highlights recent discoveries and insights into epigenetic regulatory mechanisms that modulate insect-microbe interactions. A deeper understanding of these regulatory mechanisms underlying insect-microbe interactions holds promise for the development of novel strategies for biological control of insect pests and mitigation of vector-borne diseases.
昆虫已经与多种微生物进化出了多样的相互作用，如病原真菌、细菌和病毒。昆虫宿主的免疫反应，以及微生物在应对不断变化的宿主环境和防御时的动态感染过程，都需要对基因表达程序进行快速且精确的调控。表观遗传机制，包括DNA甲基化、组蛋白修饰和非编码RNA调控，在调节参与昆虫免疫和微生物致病性的基因表达中发挥着重要作用。本综述重点介绍了调节昆虫与微生物相互作用的表观遗传调控机制的最新发现和见解。深入了解这些昆虫与微生物相互作用的调控机制，有望为开发害虫生物防治和减轻媒介传播疾病的新策略带来希望。
