Lai Yiling, Wang Lili, Zheng Weilu, Wang Sibao
CAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences (CAS), Shanghai 200032, China.
CAS Center for Excellence in Biotic Interactions, University of Chinese Academy of Sciences, Beijing 100049, China.
J Fungi (Basel). 2022 May 25;8(6):565. doi: 10.3390/jof8060565.
Filamentous fungal pathogens have evolved diverse strategies to infect a variety of hosts including plants and insects. The dynamic infection process requires rapid and fine-tuning regulation of fungal gene expression programs in response to the changing host environment and defenses. Therefore, transcriptional reprogramming of fungal pathogens is critical for fungal development and pathogenicity. Histone post-translational modification, one of the main mechanisms of epigenetic regulation, has been shown to play an important role in the regulation of gene expressions, and is involved in, e.g., fungal development, infection-related morphogenesis, environmental stress responses, biosynthesis of secondary metabolites, and pathogenicity. This review highlights recent findings and insights into regulatory mechanisms of histone methylation and acetylation in fungal development and pathogenicity, as well as their roles in modulating pathogenic fungi-host interactions.
丝状真菌病原体已经进化出多种策略来感染包括植物和昆虫在内的多种宿主。动态感染过程需要对真菌基因表达程序进行快速且精细的调节，以应对不断变化的宿主环境和防御机制。因此，真菌病原体的转录重编程对于真菌的发育和致病性至关重要。组蛋白翻译后修饰是表观遗传调控的主要机制之一，已被证明在基因表达调控中发挥重要作用，并参与例如真菌发育、感染相关形态发生、环境应激反应、次生代谢产物生物合成以及致病性等过程。本综述重点介绍了关于组蛋白甲基化和乙酰化在真菌发育和致病性中的调控机制的最新发现和见解，以及它们在调节致病真菌与宿主相互作用中的作用。
