CIB Margarita Salas - Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Trends Biochem Sci. 2024 Nov;49(11):942-954. doi: 10.1016/j.tibs.2024.07.007. Epub 2024 Oct 7.
A large fraction of soluble protein within the interior of living cells may reversibly associate with structural elements, including proteinaceous fibers and phospholipid membranes. In this opinion, we present theoretical and experimental evidence that many of these associations are due to nonspecific attraction between the protein and the surface of the fiber or membrane, and that such associations may lead to substantial changes in the association state of the adsorbed proteins, the biological function of the adsorbed proteins, and the distribution of these proteins between the many microenvironments existing within the cell.
活细胞内部的大量可溶性蛋白可能与结构元件（包括蛋白纤维和磷脂膜）可逆地结合。在这篇观点文中，我们提出了理论和实验证据，表明这些结合中的许多是由于蛋白与纤维或膜表面之间的非特异性吸引力所致，并且这种结合可能导致吸附蛋白的结合状态、吸附蛋白的生物学功能以及这些蛋白在细胞内存在的许多微环境之间的分布发生实质性变化。
