特非那定与安慰剂治疗慢性特发性荨麻疹的比较：一项随机双盲研究。
Terfenadine and placebo compared in the treatment of chronic idiopathic urticaria: a randomised double-blind study.
作者信息
Ferguson J, MacDonald K J, Kenicer K J
出版信息
Br J Clin Pharmacol. 1985 Dec;20(6):639-41. doi: 10.1111/j.1365-2125.1985.tb05122.x.
Abstract
Terfenadine, a potent and non-sedative antihistamine, was shown to be effective in chronic idiopathic urticaria in a double-blind crossover placebo controlled trial. An oral twice daily 60 mg dose of terfenadine was given and itch and wheal parameters were assessed daily. Despite the overall effectiveness of terfenadine, a variable response was noted which was similar to that shown in previous studies with other antihistamines.
摘要
特非那定是一种强效非镇静性抗组胺药，在一项双盲交叉安慰剂对照试验中显示对慢性特发性荨麻疹有效。给予每日两次口服60毫克特非那定的剂量，并每天评估瘙痒和风团参数。尽管特非那定总体有效，但仍观察到个体反应存在差异，这与先前使用其他抗组胺药的研究结果相似。
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本文引用的文献
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The pathogenic basis of urticaria and angioedema: recent advances.
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Clin Allergy. 1984 Mar;14(2):139-41. doi: 10.1111/j.1365-2222.1984.tb02644.x.
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Sedation and antihistaminics.
Arzneimittelforschung. 1982;32(9a):1193-5.
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Terfenadine, the first non-sedating antihistamine.
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Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine.使用H1组胺受体拮抗剂阿司咪唑和特非那定的性能研究。
Br J Clin Pharmacol. 1982 Feb;13(2):199-202. doi: 10.1111/j.1365-2125.1982.tb01356.x.
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Combined H1 and H2 antihistamine therapy in chronic urticaria.慢性荨麻疹的 H1 和 H2 抗组胺药联合治疗
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Assessment of tissue fluid histamine levels in patients with urticaria.荨麻疹患者组织液组胺水平的评估。
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