Izawa Y, Sagara K, Kadota T, Makita T
Calcif Tissue Int. 1985 Dec;37(6):605-7. doi: 10.1007/BF02554916.
The bones of adult (26 weeks old) spontaneously hypertensive rats (SHR) were examined chemically and histologically by comparing them with those of the corresponding normotensive Wistar-Kyoto (WKY) rats. The mean cortical thickness, the mean ash weight per unit bone volume, and the ash as percentage of dry weight of femur were significantly lower in SHR than in WKY. Besides, the percent cortical area measured on tibial cross-section was also reduced in SHR compared with WKY. These findings strongly suggest that the development of osteoporotic bone disorders exists in adult spontaneously hypertensive rats.
通过将成年（26周龄）自发性高血压大鼠（SHR）的骨骼与相应的正常血压Wistar-Kyoto（WKY）大鼠的骨骼进行比较，对其进行了化学和组织学检查。SHR的股骨平均皮质厚度、单位骨体积的平均灰重以及灰重占干重的百分比均显著低于WKY。此外，与WKY相比，SHR胫骨横截面上测量的皮质面积百分比也有所降低。这些发现有力地表明，成年自发性高血压大鼠存在骨质疏松性骨疾病的发展。
