Rattanapitak Ratanatip, Thong-Ngarm Weeranuch
Division of Crowns and Bridges, Department of Restorative Dentistry and Periodontology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.
J Prosthodont. 2024 Oct 7. doi: 10.1111/jopr.13962.
The peri-implant region, where restoration interfaces with mucosal tissue, plays an essential role in overall implant success and is just as important as osseointegration. The implant abutment materials are in intimate contact with human gingival fibroblasts (HGFs). This study compares the proliferation of HGFs between zirconia and titanium abutments used in dental implants.
An electronic search was performed using PubMed, EMBASE, and Web of Science databases. English articles based on in vitro studies testing HGFs proliferation on zirconia and titanium implant abutment materials were included. A quality assessment of the selected study was performed using the web-based Science in Risk Assessment and Policy (SciRAP) tool. The HGFs proliferation and cellular morphology tests on zirconia and titanium materials from the included studies were summarized, exploring the role of material surface characteristics.
The electronic search yielded 401 studies, of which 17 were selected for inclusion. Zirconia exhibited comparable or superior efficacy in promoting the proliferation of HGFs compared to titanium. Observations on cellular morphology showed similar outcomes for both materials. Establishing a definitive relationship between contact angle, surface roughness, and their influence on cellular response remains challenging due to the varied methodological approaches in the reviewed studies.
Based on the findings of this systematic review, zirconia shows comparable reliability to titanium as an abutment material for HGFs proliferation, with comparable or superior HGFs proliferative outcomes.
种植体周围区域是修复体与黏膜组织的界面，对种植体整体成功起着至关重要的作用，与骨结合同样重要。种植体基台材料与人类牙龈成纤维细胞（HGFs）密切接触。本研究比较了牙科种植体中氧化锆基台和钛基台对HGFs增殖的影响。
使用PubMed、EMBASE和Web of Science数据库进行电子检索。纳入基于体外研究测试氧化锆和钛种植体基台材料上HGFs增殖的英文文章。使用基于网络的风险评估与政策科学（SciRAP）工具对所选研究进行质量评估。总结纳入研究中氧化锆和钛材料上的HGFs增殖及细胞形态学测试，探讨材料表面特性的作用。
电子检索得到401项研究，其中17项被选入。与钛相比，氧化锆在促进HGFs增殖方面表现出相当或更好的效果。细胞形态学观察显示两种材料的结果相似。由于综述研究中的方法不同，确定接触角、表面粗糙度及其对细胞反应的影响之间的确切关系仍然具有挑战性。
基于本系统评价的结果，氧化锆作为一种用于HGFs增殖的基台材料，显示出与钛相当的可靠性，且具有相当或更好的HGFs增殖结果。
