Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Viikintie 49, FI-00014 Helsinki University, Finland.
Biobased Colloids and Materials, Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, P.O. Box 16300, FI-00076 Aalto, Espoo,Finland.
Biomacromolecules. 2024 Nov 11;25(11):7298-7310. doi: 10.1021/acs.biomac.4c00984. Epub 2024 Oct 8.
Despite the increasing interest in cellulose-derived materials in biomedical research, there remains a significant gap in comprehensive analyses of cellulosic materials obtained from various sources and processing methods. To explore durable alternatives to synthetic medical meshes, we evaluated the biocompatibility of bacterial nanocellulose, regenerated cellulose, and cellulose nanofibrils in a subcutaneous transplantation model, alongside incumbent polypropylene and polydioxanone. Notably, this study demonstrates the biocompatibility of regenerated cellulose obtained through alkali dissolution and subsequent regeneration. All cellulose-derived implants triggered the expected foreign body response in the host tissue, characterized predominantly by macrophages and foreign body giant cells. Porous materials promoted cell ingrowth and biointegration. Our results highlight the potential of bacterial nanocellulose and regenerated cellulose as safe alternatives to commercial polypropylene meshes. However, the fragmentation observed for cellulose nanofibril meshes suggests the need for measures to optimize their processing and preparation.
尽管人们对纤维素衍生材料在生物医学研究中的兴趣日益增加，但对于从各种来源和加工方法获得的纤维素材料的综合分析仍存在显著差距。为了探索替代合成医用网片的耐用材料，我们在皮下移植模型中评估了细菌纳米纤维素、再生纤维素和纤维素纳米纤维的生物相容性，同时也评估了现有的聚丙烯和聚二氧杂环己酮。值得注意的是，这项研究证明了通过碱溶解和随后再生获得的再生纤维素的生物相容性。所有纤维素衍生的植入物在宿主组织中引发了预期的异物反应，主要表现为巨噬细胞和异物巨细胞。多孔材料促进了细胞向内生长和生物整合。我们的结果强调了细菌纳米纤维素和再生纤维素作为商业聚丙烯网片安全替代品的潜力。然而，纤维素纳米纤维网片观察到的碎片化表明需要采取措施优化其加工和准备。
