Basista Hitender, Saxena Rohit, Pathak Vivek Kumar, Awasthi Sanjeev
Department of ENT and HNS, School of Medical Sciences and Research (SMSR), Sharda University, Greater Noida, India.
Indian J Otolaryngol Head Neck Surg. 2024 Oct;76(5):4386-4392. doi: 10.1007/s12070-024-04868-5. Epub 2024 Jul 4.
The sound sensation that is experienced in the ears or brain and is unrelated to any external sources of stimulus is known as tinnitus. Tinnitus Functional Index (TFI) is used to establish the presence of the condition and determine symptom severity, its impact on the patient's quality of life, thus in this study, we aim to compare the efficacy of caroverine and Ginkgo Biloba in the management of idiopathic tinnitus using TFI.
This clinical study was conducted in at a tertiary care hospital in North India, for a duration of one year, among patients with chronic tinnitus. The sample size for this study consisted of 60 patients in each of three groups (caroverine, gingko biloba, and multivitamin). Assessments of TFI and pure-tone audiometry were performed to evaluate the efficacy of the two medications. The information pertaining to the subjects was kept anonymous and confidential. During data analysis, an association was significant for p value < 0.05.
The patients in three groups were matched for the age, gender and duration of tinnitus. At 6 months of medication with Ginkgo Biloba, patients experienced a significant ( < 0.0001) decrease of 50.0% in tinnitus of moderate severity, and a complete resolution of severe tinnitus symptoms with a percentage change of -100.0%.
In our study, Ginkgo Biloba Group has significantly improved the severity of idiopathic tinnitus. Tinnitus has diverse underlying mechanisms, can be a symptom of various underlying diseases, and is challenging to measure. Further research is warranted to validate and explore these treatment options further.
耳鸣是指在耳朵或大脑中感受到的、与任何外部刺激源无关的声音感觉。耳鸣功能指数（TFI）用于确定该病症的存在并确定症状严重程度及其对患者生活质量的影响，因此在本研究中，我们旨在使用TFI比较卡维林和银杏叶在特发性耳鸣管理中的疗效。
这项临床研究在印度北部的一家三级护理医院进行，为期一年，研究对象为慢性耳鸣患者。本研究的样本量包括三组（卡维林、银杏叶和多种维生素）中的每组60名患者。进行TFI评估和纯音听力测定以评估两种药物的疗效。与受试者相关的信息保持匿名和保密。在数据分析期间，p值<0.05时关联具有显著性。
三组患者在年龄、性别和耳鸣持续时间方面相匹配。在使用银杏叶治疗6个月时，中度严重程度耳鸣患者的耳鸣显著（<0.0001）降低了50.0%，重度耳鸣症状完全缓解，百分比变化为-100.0%。
在我们的研究中，银杏叶组显著改善了特发性耳鸣的严重程度。耳鸣有多种潜在机制，可能是各种潜在疾病的症状，且测量具有挑战性。有必要进行进一步研究以验证并进一步探索这些治疗选择。
