Otology and hearing group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, NG7 2RD, UK.
National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham, NG1 5DU, UK.
Health Qual Life Outcomes. 2018 Apr 11;16(1):61. doi: 10.1186/s12955-018-0888-9.
There are a large number of assessment tools for tinnitus, with little consensus on what it is important to measure and no preference for a minimum reporting standard. The item content of tinnitus assessment tools should seek to capture relevant impacts of tinnitus on everyday life, but no-one has yet synthesised information about the range of tinnitus complaints. This review is thus the first comprehensive and authoritative collection and synthesis of what adults with tinnitus and their significant others report as problems in their everyday lives caused by tinnitus.
Electronic searches were conducted in PubMed, Embase, CINAHL, as well as grey literature sources to identify publications from January 1980 to June 2015 in which participants were enrolled because tinnitus was their primary complaint. A manual search of seven relevant journals updated the search to December 2017. Of the 3699 titles identified overall, 84 records (reporting 86 studies) met our inclusion criteria and were taken through to data collection. Coders collated generic and tinnitus-specific complaints reported by people with tinnitus. All relevant data items were then analyzed using an iterative approach to narrative synthesis to form domain groupings representing complaints of tinnitus, which were compared patients and significant others.
From the 86 studies analyzed using data collected from 16,381 patients, 42 discrete complaints were identified spanning physical and psychological health, quality of life and negative attributes of the tinnitus sound. This diversity was not captured by any individual study alone. There was good convergence between complaints collected using open- and closed-format questions, with the exception of general moods and perceptual attributes of tinnitus (location, loudness, pitch and unpleasantness); reported only using closed questions. Just two studies addressed data from the perspective of significant others (n = 79), but there was substantial correspondence with the patient framework, especially regarding relationships and social life.
Our findings contribute fundamental new knowledge and a unique resource that enables investigators to appreciate the broad impacts of tinnitus on an individual. Our findings can also be used to guide questions during diagnostic assessment, to evaluate existing tinnitus-specific HR-QoL questionnaires and develop new ones, where necessary.
PROSPERO registration number: CRD42015020629 . Protocol published in BMJ Open. 2016;6e009171.
有大量的耳鸣评估工具，但对于什么是重要的评估指标以及对最低报告标准的偏好尚未达成共识。耳鸣评估工具的项目内容应旨在捕捉耳鸣对日常生活的相关影响，但还没有人综合了解耳鸣投诉的范围。因此，本综述是第一次全面、权威地收集和综合了耳鸣患者及其重要他人报告的日常生活中因耳鸣而引起的各种问题。
在 PubMed、Embase、CINAHL 以及灰色文献资源中进行电子检索，以确定自 1980 年 1 月至 2015 年 6 月间因耳鸣为主要抱怨而招募参与者的出版物。对七本相关期刊的手工检索将检索更新至 2017 年 12 月。在总共 3699 个标题中，有 84 个记录（报告了 86 项研究）符合我们的纳入标准，并通过数据收集进入下一步。编码员整理了耳鸣患者报告的一般和耳鸣特有的抱怨。然后使用迭代叙述性综合方法分析所有相关数据项，形成代表耳鸣抱怨的领域分组，并将其与患者和重要他人进行比较。
从使用 16381 名患者的数据进行分析的 86 项研究中，共确定了 42 种离散的抱怨，涵盖了身体和心理健康、生活质量以及耳鸣声音的负面属性。这种多样性无法由任何单一研究单独捕捉到。开放式和封闭式问题收集的抱怨之间有很好的一致性，除了一般情绪和耳鸣的感知属性（位置、响度、音调和不愉快），这些只能通过封闭式问题来报告。只有两项研究从重要他人的角度（n=79）收集了数据，但与患者框架有很大的一致性，特别是在人际关系和社会生活方面。
我们的研究结果提供了基本的新知识和独特的资源，使研究人员能够了解耳鸣对个人的广泛影响。我们的研究结果还可以用于指导诊断评估期间的问题，评估现有的耳鸣特定 HR-QoL 问卷，并在必要时开发新的问卷。
PROSPERO 注册号：CRD42015020629。方案发表于 BMJ Open。2016；6e009171。
