Liu Chun-Kuei, Su Fang-Yi, Juang Tzong-Yuan, Liu Yung-Chuan
Department of Chemical Engineering, National Chung Hsing University 145 Xingda Rd., South Dist. Taichung 40227 Taiwan
Department of Cosmeceutics, China Medical University Taichung 40402 Taiwan
RSC Adv. 2024 Oct 7;14(43):31694-31703. doi: 10.1039/d4ra05587j. eCollection 2024 Oct 1.
This study introduces zwitterionic hyperbranched polymer (HBP) dots intercalated into layered double hydroxides (LDHs) for sustained antibacterial release. The proposed zwitterionic HBPs possess a three-dimensional spherical structure; unconventional blue fluorescent luminescence; water solubility; abundant COOH, amine, and amide functional groups; anionic exchangeability for intercalating into LDH interlayers; and sustained-release antibacterial activity. The intercalation for the layered nanomaterials was determined by adding different weight ratios of HBPs to Mg-Al LDHs to investigate the changes in the interlayer distance. X-ray diffraction revealed that the LDH layer spacing increased from 8.6 to 25.5 Å, effectively expanding the interlayer spacing with increasing HBP intercalation. Additionally, Fourier-transform infrared spectroscopy revealed the functional groups of the intercalated nanohybrids. Because the peripheral functional groups of HBPs are amino (-NH) groups, preliminary evaluations revealed that pristine HBPs exhibited antibacterial properties. We further examined the antibacterial properties of the HBP/LDH nanohybrids. The results showed that HBPs combined with LDHs' controllable release properties can effectively achieve long-term sustained antibacterial release.
本研究介绍了嵌入层状双氢氧化物（LDH）中的两性离子超支化聚合物（HBP）点用于持续抗菌释放。所提出的两性离子HBP具有三维球形结构；非常规蓝色荧光发光；水溶性；丰富的COOH、胺和酰胺官能团；可通过阴离子交换嵌入LDH层间；以及持续释放抗菌活性。通过向Mg-Al LDH中添加不同重量比的HBP来研究层状纳米材料的嵌入情况，以考察层间距的变化。X射线衍射表明，随着HBP嵌入量的增加，LDH层间距从8.6 Å增加到25.5 Å，有效地扩大了层间距。此外，傅里叶变换红外光谱揭示了嵌入纳米杂化物的官能团。由于HBP的外围官能团是氨基（-NH）基团，初步评估表明原始HBP具有抗菌性能。我们进一步研究了HBP/LDH纳米杂化物的抗菌性能。结果表明，HBP与LDH的可控释放特性相结合，可以有效地实现长期持续抗菌释放。
