Bag Neelanjana, Bardhan Souravi, Roy Shubham, Roy Jhilik, Mondal Dhananjoy, Guo Bing, Das Sukhen
Department of Physics, Jadavpur University, Kolkata-700032, India.
Department of Environmental Science, Netaji Nagar College for Women, Kolkata-700092, India.
Biomater Sci. 2023 Mar 14;11(6):1994-2019. doi: 10.1039/d2bm01941h.
The limitations associated with conventional antibacterial therapies and the subsequent amplification of multidrug-resistant (MDR) microorganisms have increased, necessitating the urgent development of innovative antibacterial techniques. Accordingly, nanoparticle-mediated therapeutics have emerged as potential candidates for antibacterial treatment due to their suitable dimensions, penetration capacity, and high efficiency in targeted drug delivery. However, although nanoparticle-based drug delivery systems have been demonstrated to be effective, they are limited by their overuse and unwanted side effects. Thus, to overcome these drawbacks, stimulus-responsive antibiotic delivery has been extended as a promising strategy for site-specific restricted drug exemption. Nano-formulations that are triggered by various stimuli, such as intrinsic, extrinsic, and bacterial stimuli, have been developed. Thus, by harnessing the physicochemical properties of various nanoparticles, the selective release of therapeutic cargoes can be achieved through the application of a variety of local stimuli such as light, sound, irradiation, pH, and magnetic field. In this review, we also highlight the progress and perspectives of stimulus-responsive combination therapy, with special emphasis on the eradication of MDR strains and biofilms. Hence, this review addresses the advancement and challenges in the applications of stimulus-responsive nanoparticles together with the various future prospects of this technique.
传统抗菌疗法的局限性以及随后多重耐药（MDR）微生物的增加，使得迫切需要开发创新的抗菌技术。因此，纳米颗粒介导的疗法因其合适的尺寸、穿透能力和靶向药物递送的高效率，已成为抗菌治疗的潜在候选方法。然而，尽管基于纳米颗粒的药物递送系统已被证明是有效的，但它们因过度使用和不良副作用而受到限制。因此，为了克服这些缺点，刺激响应性抗生素递送已作为一种有前景的策略被推广，用于位点特异性受限药物释放。已经开发出由各种刺激（如内在、外在和细菌刺激）触发的纳米制剂。因此，通过利用各种纳米颗粒的物理化学性质，可以通过应用各种局部刺激（如光、声、辐射、pH值和磁场）来实现治疗性货物的选择性释放。在本综述中，我们还强调了刺激响应性联合疗法的进展和前景，特别强调了对多重耐药菌株和生物膜的根除。因此，本综述探讨了刺激响应性纳米颗粒应用中的进展和挑战以及该技术的各种未来前景。
