Najjaran Marzieh, Zarei-Ghanavati Siamak, Ostadimoghaddam Hadi, Yekta Abbasali, Shoeibi Nasser, Hemmati Armin, Abrishami Mojtaba, Akhlaghi Saeed, Ziaei Mohammed
Department of Optometry School of Paramedical Sciences and Rehabilitation Mashhad University of Medical Sciences, Mashhad, Iran.
Refractive Errors Research Center Mashhad University of Medical Sciences, Mashhad, Iran.
J Ophthalmol. 2024 Sep 30;2024:2381582. doi: 10.1155/2024/2381582. eCollection 2024.
To compare biometric and optical coherence tomography parameters as well as refractive status in preterm children aged 4-8 years with or without retinopathy of prematurity (ROP), and evaluate their correlations with age and gender-matched full-term children.
Retrospective comparative cohort study of four groups of children. Children with a history of preterm birth, including ROP who received intravitreal bevacizumab (IVB) treatment, children with a history of ROP that regressed without treatment and those with no history of ROP were compared to age and gender-matched full-term children as a control group. Best corrected visual acuity (BCVA), spherical equivalent of refraction (SE), macular and choroidal thickness, as well as biometric parameters was measured.
A total of 120 eyes of 120 children (30 children in each group) were included. There was no significant difference in BCVA, SE, and subjective cylinder between groups (=0.05, =0.3, =0.6, respectively). Axial length was significantly shorter, and the cornea was steeper in both ROP groups than in other groups (=0.001, < 0.001, respectively). The central macular thickness was significantly thicker in the treated, regressed ROP and preterm groups than in full-term children ( < 0.001). The gestational age was negatively correlated with macular thickness in both treated and regressed ROP groups ( = -0.517; =0.003, = - 0.490; =0.006, respectively).
Children with a history of ROP had a shorter axial length, steeper cornea, and thicker macula that correlated with lower gestational age.
比较4至8岁患有或未患早产儿视网膜病变（ROP）的早产儿的生物测量和光学相干断层扫描参数以及屈光状态，并评估它们与年龄和性别匹配的足月儿的相关性。
对四组儿童进行回顾性比较队列研究。将有早产史的儿童，包括接受玻璃体内注射贝伐单抗（IVB）治疗的ROP患儿、ROP病史未经治疗而自行消退的患儿以及无ROP病史的患儿，与年龄和性别匹配的足月儿作为对照组进行比较。测量最佳矫正视力（BCVA）、等效球镜度（SE）、黄斑和脉络膜厚度以及生物测量参数。
共纳入120名儿童的120只眼（每组30名儿童）。各组之间的BCVA、SE和主观柱镜度无显著差异（分别为P=0.05、P=0.3、P=0.6）。两个ROP组的眼轴长度均显著短于其他组，角膜曲率均比其他组更陡峭（分别为P=0.001、P<0.001）。接受治疗、自行消退的ROP组和早产组的中心黄斑厚度均显著厚于足月儿（P<0.001）。在接受治疗和自行消退的ROP组中，胎龄与黄斑厚度均呈负相关（分别为r=-0.517，P=0.003；r=-0.490，P=0.006）。
有ROP病史的儿童眼轴较短、角膜较陡峭、黄斑较厚，且与较低的胎龄相关。
