早产儿无早产儿视网膜病变的眼生物测量和光学相干断层扫描参数评估。
Evaluation of Ocular Biometric and Optical Coherence Tomography Parameters in Preterm Children Without Retinopathy of Prematurity.
机构信息
Department of Ophthalmology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latiff, Bandar Tun Razak, Cheras, Kuala Lumpur, Malaysia.
Department of Ophthalmology, Sunway Medical Centre Jalan Lagoon Selatan, Bandar Sunway, Petaling Jaya, Selangor, Malaysia.
出版信息
Transl Vis Sci Technol. 2022 Mar 2;11(3):8. doi: 10.1167/tvst.11.3.8.
PURPOSE
To evaluate and compare biometric and optical coherence tomography parameters of ocular structures in preterm children without retinopathy of prematurity with term children.
METHODS
A cross-sectional, comparative study was carried out from 2018 to 2019. In this study, 124 eyes of 62 preterm children were compared with 132 eyes of 66 term children aged between 7 and 9 years. Preterm children were born at 28 to 32 weeks with a birth weight of less than 2 kg with no ocular abnormalities, and term children were delivered at 37 or greater weeks and had a birth weight of 2 kg or more. All children had standardized eye examinations, and ocular measurements using the anterior and posterior segment optical coherence tomography and laser interferometry.
RESULTS
Significant differences were found between the term and preterm children for horizontal corneal diameter: median, 12.2 mm (interquartile range [IQR], 0.4) versus median, 12.1 mm (IQR, 0.6; P < 0.005); axial length median, 23.03 mm (IQR, 1.10 mm) versus median, 22.88 mm (IQR, 1.35 mm; P = 0.017); global retinal nerve fiber layer thickness: mean ± standard deviation, 106.54 ± 10.23 µm versus mean ± standard deviation, 103.65 ± 10.178 µm (P = 0.024); temporal retinal nerve fiber layer thickness: median, 76 µm (IQR, 16 µm) vs median, 74 µm (IQR, 14 µm; P = 0.012); and the angle opening distance at 750 µm nasal: mean ± standard deviation, 0.815 ± 0.23 mm vs mean ± standard deviation, 0.749 ± 0.21 mm (P = 0.016). No significant differences were found for other anterior segment and angle parameters.
CONCLUSIONS
Preterm children with no retinopathy of prematurity have smaller eyes and thinner retinal nerve fiber layers than their term counterparts. The long-term effects of interrupted ocular growth in preterm children should be further studied into adulthood.
TRANSLATIONAL RELEVANCE
Preterm children maybe more predisposed to certain eye conditions because they have smaller eyes, and thus should be further monitored clinically.
目的
评估和比较无早产儿视网膜病变的早产儿与足月儿童的眼部生物测量和光相干断层扫描参数。
方法
这是一项 2018 年至 2019 年进行的横断面、对比研究。本研究比较了 62 名早产儿的 124 只眼和 66 名足月儿童的 132 只眼，这些足月儿童的胎龄为 37 周或以上，出生体重为 2 公斤或以上。所有儿童均进行了标准化眼部检查，并使用眼前段和后段光学相干断层扫描及激光干涉仪进行眼部测量。
结果
足月儿童与早产儿的水平角膜直径存在显著差异：中位数分别为 12.2mm（四分位距 [IQR]，0.4）和 12.1mm（IQR，0.6；P<0.005）；眼轴长度中位数分别为 23.03mm（IQR，1.10mm）和 22.88mm（IQR，1.35mm；P=0.017）；全视网膜神经纤维层厚度平均值±标准差分别为 106.54±10.23µm 和 103.65±10.178µm（P=0.024）；颞侧视网膜神经纤维层厚度中位数分别为 76µm（IQR，16µm）和 74µm（IQR，14µm；P=0.012）；750µm 鼻侧开口距离平均值±标准差分别为 0.815±0.23mm 和 0.749±0.21mm（P=0.016）。其他眼前段和角度参数无显著差异。
结论
无早产儿视网膜病变的早产儿眼睛较小，视网膜神经纤维层较薄。早产儿眼部生长中断的长期影响应进一步研究至成年。
翻译
无早产儿视网膜病变的早产儿与足月儿童的眼部生物测量和光相干断层扫描参数的评估和比较。
方法
这是一项 2018 年至 2019 年进行的横断面、对比研究。本研究比较了 62 名早产儿的 124 只眼和 66 名足月儿童的 132 只眼，这些足月儿童的胎龄为 37 周或以上，出生体重为 2 公斤或以上。所有儿童均进行了标准化眼部检查，并使用眼前段和后段光学相干断层扫描及激光干涉仪进行眼部测量。
结果
足月儿童与早产儿的水平角膜直径存在显著差异：中位数分别为 12.2mm（四分位距 [IQR]，0.4）和 12.1mm（IQR，0.6；P<0.005）；眼轴长度中位数分别为 23.03mm（IQR，1.10mm）和 22.88mm（IQR，1.35mm；P=0.017）；全视网膜神经纤维层厚度平均值±标准差分别为 106.54±10.23µm 和 103.65±10.178µm（P=0.024）；颞侧视网膜神经纤维层厚度中位数分别为 76µm（IQR，16µm）和 74µm（IQR，14µm；P=0.012）；750µm 鼻侧开口距离平均值±标准差分别为 0.815±0.23mm 和 0.749±0.21mm（P=0.016）。其他眼前段和角度参数无显著差异。
结论
无早产儿视网膜病变的早产儿眼睛较小，视网膜神经纤维层较薄。早产儿眼部生长中断的长期影响应进一步研究至成年。
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