The Science of Solid Lipid Nanoparticles: From Fundamentals to Applications.

Solid lipid nanoparticles (SLNs) play a crucial role in drug delivery, offering benefits such as enhanced bioavailability, targeted distribution, and reduced toxicity. This article provides a comprehensive overview of SLN formulation, development, and advancement in pharmaceutical research, examining their characteristics, classifications, and significance. The review also delves into the real-world applicability of various SLN formulations across different routes of administration, discussing their advantages, disadvantages, and challenges of scalability, along with strategies for efficient implementation. Furthermore, it explores the diverse applications of SLNs through various delivery methods, addressing the obstacles and potential solutions. By highlighting the critical role of SLNs in improving treatment outcomes, this review underscores their importance in modern drug delivery systems.