Rodriguez Analiz, Ahluwalia Manmeet S, Bettegowda Chetan, Brem Henry, Carter Bob S, Chang Susan, Das Sunit, Eberhart Charles, Garzon-Muvdi Tomas, Hadjipanayis Costas G, Hawkins Cynthia, Jacques Thomas S, Khalessi Alexander A, McDermott Michael W, Mikkelsen Tom, Orr Brent A, Phillips Joanna J, Rosenblum Mark, Shelton William J, Solomon David A, von Deimling Andreas, Woodworth Graeme F, Rutka James T
Department of Neurosurgery, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States.
Department of Medical Oncology, Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States.
Front Oncol. 2024 Sep 23;14:1471257. doi: 10.3389/fonc.2024.1471257. eCollection 2024.
Implementation of standardized protocols in neurooncology during the surgical resection of brain tumors is needed to advance the clinical treatment paradigms that use tissue for diagnosis, prognosis, bio-banking, and treatment. Currently recommendations on intraoperative tissue procurement only exist for diffuse gliomas but management of other brain tumor subtypes can also benefit from these protocols. Fresh tissue from surgical resection can now be used for intraoperative diagnostics and functional precision medicine assays. A multidisciplinary neuro-oncology perspective is critical to develop the best avenues for practical standardization. This perspective from the multidisciplinary Oncology Tissue Advisory Board (OTAB) discusses current advances, future directions, and the imperative of adopting standardized protocols for diverse brain tumor entities. There is a growing need for consistent operating room practices to enhance patient care, streamline research efforts, and optimize outcomes.
在脑肿瘤手术切除过程中实施神经肿瘤学标准化方案，对于推进利用组织进行诊断、预后评估、生物样本库建设及治疗的临床治疗模式至关重要。目前，关于术中组织采集的建议仅适用于弥漫性胶质瘤，但其他脑肿瘤亚型的管理也可从这些方案中受益。手术切除获得的新鲜组织现在可用于术中诊断和功能精准医学检测。多学科神经肿瘤学视角对于开发最佳实用标准化途径至关重要。多学科肿瘤组织咨询委员会（OTAB）的这一观点讨论了当前进展、未来方向以及为不同脑肿瘤实体采用标准化方案的必要性。对一致的手术室操作的需求日益增长，以加强患者护理、简化研究工作并优化治疗结果。
