Prusty Amaresh, Jena Bikash Ranajn, Barik Vivek, Khamkat Piyali, Barik Bhakti Bhusan
Department of Pharmaceutics, Royal College of Pharmacy and Health Sciences, Berhampur, Odisha, 760002, India.
Department of Pharmaceutical Analysis, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, 752050, India.
Curr Drug Discov Technol. 2024 Oct 4. doi: 10.2174/0115701638318659240923074614.
Most of the newly discovered drug candidates are lipophilic and poorly water-soluble, making it a significant challenge for the pharmaceutical industry to formulate suitable drug delivery systems. This review gives insight into an overview of the liquisolid technique (LST) and summarizes the progress of its various applications in drug delivery. This novel technique involves converting liquid drugs or drugs in a liquid state (such as solutions, suspensions, or emulsions) into dry, nonadherent, free-flowing, and readily compressible powder mixtures by blending or spraying a liquid dispersion onto specific powder carriers and coating materials. In Liquisolid systems, the liquid medication is absorbed into the interior framework of carriers. Once the carrier's interior is saturated with liquid medication, a liquid layer forms on the surface of the carrier particles, which is instantly adsorbed by the fine coating material. As a result, a dry, free-flowing, and compressible powder mixture is formed. Compared to other solubility enhancement techniques, s.a. micronization, inclusion complexation, microencapsulation, nanosuspension, and self-nano emulsions, LST is relatively simple to prepare and may offer a cost-effective solution to enhance the solubility of poorly water-soluble drugs enhancing its bioavailability in drug formulation and delivery.
大多数新发现的候选药物具有亲脂性且水溶性差，这给制药行业开发合适的药物递送系统带来了重大挑战。本综述深入介绍了液固技术（LST）的概况，并总结了其在药物递送中的各种应用进展。这种新技术是通过将液体药物或液态药物（如溶液、混悬液或乳剂）与特定的粉末载体和包衣材料混合或喷雾液体分散体，将其转化为干燥、不粘连、自由流动且易于压缩的粉末混合物。在液固系统中，液体药物被吸收到载体的内部结构中。一旦载体内部被液体药物饱和，载体颗粒表面就会形成一层液体层，该液体层会立即被细包衣材料吸附。结果，形成了一种干燥、自由流动且可压缩的粉末混合物。与其他溶解度提高技术（如微粉化、包合络合、微囊化、纳米混悬液和自纳米乳剂）相比，液固技术制备相对简单，可能为提高难溶性药物的溶解度提供一种经济有效的解决方案，从而提高其在药物制剂和递送中的生物利用度。
