Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, India.
Drug Dev Ind Pharm. 2024 May;50(5):387-400. doi: 10.1080/03639045.2024.2345131. Epub 2024 Apr 24.
TheDES are formed by mixing a Hydrogen Bond Donor (HBD) and a Hydrogen Bond Acceptor (HBA) in appropriate molar ratios. These solvents have been shown to enhance drug solubility, permeability, and delivery. The main objective of the present article is to review these advantages of TheDES.
TheDES show unique properties, such as low toxicity, biodegradability, improved bioavailability and enhanced drug delivery of poorly soluble active pharmaceutical ingredients. They are also biocompatible in nature which makes them a promising candidate for various therapeutic applications, including drug formulations, drug delivery and other biomedical uses. The development and utilization of TheDES shows significant advancement in pharmaceutical research, providing new opportunities for improving drug delivery.
The current study was carried out by conducting a systematic literature review that identified relevant papers from indexed databases. Numerous studies and research are cited and quoted in this article to demonstrate the effectiveness of TheDES in enhancing drug solubility, permeability, and delivery. All chosen articles were selected considering their significance, quality, and approach to addressing issues.
As a result, various TheDES were identified that can be formulated in different ways: one component can act as a vehicle for an API, either HBD or HBA can be an API, both HBD and HBA can be APIs, or the individual components of DES are not therapeutically active but the resulting DES possesses therapeutic activity. Additionally, TheDES were also recognized to enhance drug delivery and solubility for different APIs, including NSAIDs, anesthetic drugs, antifungals, and others.
DES 是通过以适当的摩尔比混合氢键供体 (HBD) 和氢键受体 (HBA) 形成的。这些溶剂已被证明可以提高药物的溶解度、渗透性和传递性。本文的主要目的是综述这些 DES 的优势。
DES 具有独特的性质，如低毒性、可生物降解性、提高生物利用度和增强难溶性活性药物成分的药物传递。它们在本质上具有生物相容性，这使它们成为各种治疗应用的有前途的候选物，包括药物制剂、药物传递和其他生物医学用途。DES 的开发和利用在药物研究方面取得了重大进展，为改善药物传递提供了新的机会。
本研究通过系统文献综述进行，从索引数据库中确定了相关论文。本文引用和引用了大量的研究和研究来证明 DES 在提高药物溶解度、渗透性和传递性方面的有效性。所有选定的文章都是根据其重要性、质量和解决问题的方法来选择的。
结果发现了各种 DES，可以以不同的方式进行配方：一种成分可以作为 API 的载体，HBD 或 HBA 可以作为 API，HBD 和 HBA 都可以作为 API，或者 DES 的各个成分没有治疗活性，但产生的 DES 具有治疗活性。此外，DES 还被认为可以提高不同 API（包括 NSAIDs、麻醉药物、抗真菌药物等）的药物传递和溶解度。
