Department of Hepatobiliary Surgery II, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.
J Extracell Vesicles. 2024 Oct;13(10):e12521. doi: 10.1002/jev2.12521.
Bacterial extracellular vesicles (BEVs) have emerged as pivotal mediators between bacteria and host. In addition to being crucial players in host homeostasis, they have recently been implicated in disease pathologies such as cancer. Hence, the study of BEVs represents an intriguing and rapidly evolving field with substantial translational potential. In this review, we briefly introduce the fundamentals of BEV characteristics, cargo and biogenesis. We emphatically summarize the current relationship between BEVs across various cancer types, illustrating their role in tumorigenesis, treatment responses and patient survival. We further discuss the inherent advantages of BEVs, such as stability, abundance and specific cargo profiles, that make them attractive candidates for non-invasive diagnostic and prognostic approaches. The review also explores the potential of BEVs as a strategy for cancer therapy, considering their ability to deliver therapeutic agents, modulate the tumour microenvironment (TME) and elicit immunomodulatory responses. Understanding the clinical significance of BEVs may lead to the development of better-targeted and personalized treatment strategies. This comprehensive review evaluates the current progress surrounding BEVs and poses questions to encourage further research in this emerging field to harness the benefits of BEVs for their full potential in clinical applications against cancer.
细菌细胞外囊泡（BEVs）已成为细菌与宿主之间的重要介质。除了在宿主内稳态中起着关键作用外，它们最近还与癌症等疾病病理学有关。因此，BEV 的研究代表了一个有趣且快速发展的领域，具有巨大的转化潜力。在这篇综述中，我们简要介绍了 BEV 特征、货物和生物发生的基础。我们着重总结了 BEVs 在各种癌症类型中的当前关系，说明了它们在肿瘤发生、治疗反应和患者生存中的作用。我们进一步讨论了 BEVs 的固有优势，如稳定性、丰度和特定货物谱，这使它们成为非侵入性诊断和预后方法的有吸引力的候选者。该综述还探讨了 BEVs 作为癌症治疗策略的潜力，考虑到它们能够输送治疗剂、调节肿瘤微环境（TME）并引发免疫调节反应。了解 BEVs 的临床意义可能会导致开发更有针对性和个性化的治疗策略。本综述全面评估了 BEVs 的当前进展，并提出了一些问题，以鼓励在这一新兴领域进一步研究，充分利用 BEVs 在癌症临床应用中的潜力。
