棕色脂肪组织与衰老：运动的潜在作用。
Brown adipose tissue and aging: A potential role for exercise.
机构信息
Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Division of Preventive Medicine, Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan.
Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA; Department of Physiology and Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
出版信息
Exp Gerontol. 2023 Jul;178:112218. doi: 10.1016/j.exger.2023.112218. Epub 2023 May 29.
Aging is one of the primary risk factors for the development of type 2 diabetes and cardiovascular disease, and regular physical activity can help to delay, prevent, or manage the onset and development of many chronic diseases present in older adults. Brown adipose tissue (BAT) is thermogenic tissue that protects against age-related disease, but BAT activity decreases with age. In this review, we discuss how aging contributes to impaired BAT function by inducing a 'whitening' of the BAT and altering beta 3 adrenergic receptor (βAR) signaling, uncoupling protein 1 (UCP1) gene expression, and mitochondria respiration, and potential mechanisms for exercise to counteract the effects of aging on BAT.
衰老是 2 型糖尿病和心血管疾病发展的主要危险因素之一，而有规律的身体活动有助于延缓、预防或控制老年人中许多慢性疾病的发生和发展。棕色脂肪组织（BAT）是一种产热组织，可预防与年龄相关的疾病，但 BAT 活性随年龄增长而下降。在这篇综述中，我们讨论了衰老如何通过诱导 BAT 的“白化”以及改变β3 肾上腺素能受体（βAR）信号、解偶联蛋白 1（UCP1）基因表达和线粒体呼吸来导致 BAT 功能受损，并讨论了运动对抗衰老对 BAT 影响的潜在机制。
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