胰腺癌的进化树

The Evolutionary Forest of Pancreatic Cancer.

作者信息

Mullen Katelyn M, Hong Jungeui, Attiyeh Marc A, Hayashi Akimasa, Sakamoto Hitomi, Kohutek Zachary A, McIntyre Caitlin A, Zhang Haochen, Makohon-Moore Alvin P, Zucker Amanda, Wood Laura D, Myers Matthew A, Arnold Brian J, Zaccaria Simone, Chou Joanne F, Capanu Marinela, Socci Nicholas D, Raphael Benjamin J, Iacobuzio-Donahue Christine A

机构信息

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York.

Division of Gastrointestinal Pathology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland.

出版信息

Cancer Discov. 2025 Feb 7;15(2):329-345. doi: 10.1158/2159-8290.CD-23-1541.

Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.