Department of Internal Medicine, Endocrinology and Metabolism Unit, Bahir Dar University, Bahir Dar, Ethiopia.
Department of Internal Medicine, Adama Hospital Medical College, Adama, Ethiopia.
BMC Endocr Disord. 2024 Oct 8;24(1):211. doi: 10.1186/s12902-024-01741-y.
Arginine vasopressin deficiency (central diabetes insipidus) is defined as a reduction in the release of arginine vasopressin (AVP) resulting in a variable degree of polyuria. Partial empty sella refers to an enlarged sella turcica that is not completely filled by pituitary gland. It can be either primary or secondary and its manifestation ranges from asymptomatic cases to isolated posterior pituitary, isolated anterior pituitary or both anterior and posterior pituitary dysfunctions. Diabetes insipidus caused by a partially empty sella is rare.
The patient, an 18-year-old Ethiopian woman who presented with long standing headache, increased urination, increased thirst, absence of menses and weight loss. Urine and serum osmolality was done and suggested diabetes insipidus. On further workup, brain magnetic resonant imaging was done and partially empty sella was diagnosed.
Diabetes insipidus secondary to partially empty sella is uncommon. In patients presenting with headache and anterior or posterior pituitary dysfunction, empty sella should be considered, whether partial or complete.
精氨酸加压素缺乏症（中枢性尿崩症）定义为精氨酸加压素（AVP）释放减少，导致不同程度的多尿。部分空蝶鞍是指蝶鞍扩大，垂体组织未完全填充蝶鞍。它可以是原发性的也可以是继发性的，其表现从无症状病例到孤立性垂体后叶、孤立性垂体前叶或垂体前叶和后叶功能障碍均可。由部分空蝶鞍引起的尿崩症较为罕见。
患者是一位 18 岁的埃塞俄比亚女性，长期头痛、多尿、口渴、闭经和体重减轻。进行了尿液和血清渗透压检查，提示尿崩症。进一步检查发现，脑磁共振成像显示部分空蝶鞍。
继发于部分空蝶鞍的尿崩症并不常见。在出现头痛和垂体前叶或后叶功能障碍的患者中，无论空蝶鞍是部分性还是完全性，都应考虑到空蝶鞍。
