Liu Bosheng, Dong Jinxu, Zhu Qi, Zhang Jundong, Huang Jian, Liu Shiwen, Zeng Xiaojun
School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, Jiangxi, 330031, China.
College of Textiles and Clothing, Yancheng Institute of Technology, Jiangsu, 224003, China.
Chem Commun (Camb). 2024 Oct 24;60(86):12537-12540. doi: 10.1039/d4cc04307c.
Herein, we present a highly efficient copper-catalyzed protocol for transforming propargyl -dichlorides into the corresponding chloro-substituted fluoroalkylated allenes. This protocol demonstrates a broad substrate scope and excellent tolerance towards various functional groups. Moreover, the strategy of utilizing the chloro-substituted pentafluoroethylation allenes for multiple transformations has shown significant value in synthetic chemistry.
