微小RNA作为脑肿瘤的生物标志物
MicroRNAs as Biomarkers of Brain Tumor.
作者信息
Jelski Wojciech, Mroczko Barbara
机构信息
Department of Biochemical Diagnostics, Medical University, Bialystok, Poland.
Department of Neurodegeneration Diagnostics, Medical University, Bialystok, Poland.
出版信息
Cancer Manag Res. 2024 Oct 4;16:1353-1361. doi: 10.2147/CMAR.S484158. eCollection 2024.
Brain tumors have been deadly cancers for years, and in most cases they are difficult to diagnose in their early stages. For this reason, researchers need to develop low-cost, sensitive methods for examining cancer biomarkers. Such biomarkers include microRNA. MicroRNA expression in various body fluids shows a high correlation with cancer. A number of studies have demonstrated changes in microRNA expression in cerebrospinal fluid and blood samples from patients with brain tumors. New biomarkers such as microRNAs may help diagnose brain tumors at the very beginning of the disease, enabling early treatment and increasing the chances of survival. This review describes the diagnostic role of microRNAs and the prospects for their use as biomarkers in patients with brain tumors.
多年来，脑肿瘤一直是致命的癌症，而且在大多数情况下，它们在早期很难被诊断出来。因此，研究人员需要开发低成本、高灵敏度的方法来检测癌症生物标志物。此类生物标志物包括微小RNA。微小RNA在各种体液中的表达与癌症高度相关。多项研究已经证明，脑肿瘤患者脑脊液和血液样本中的微小RNA表达存在变化。诸如微小RNA之类的新生物标志物可能有助于在疾病最早期诊断脑肿瘤，从而实现早期治疗并增加存活几率。这篇综述描述了微小RNA的诊断作用及其作为脑肿瘤患者生物标志物的应用前景。
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