Yuan Zhaoxia, Zhang Jiahao, Jiang Danli, Huang Guangyu, Qi Wenbao
College of Animal Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510642, China.
State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
One Health. 2024 Sep 12;19:100893. doi: 10.1016/j.onehlt.2024.100893. eCollection 2024 Dec.
H10 subtype avian influenza viruses were endemic in wild and domestic avian species worldwide. Strikingly, it frequently crossed the species barrier to infect mammalian hosts. Human infection with H10N3 and H10N8 were reported previously. Recently, a 63-year-old woman from Anhui province of China who died from a mixed infection of H3N2 and H10N5 influenza viruses, which have drawn widespread public health attention. Here, we perform the evolutionary dynamics of H10N5 influenza viruses of bird- and human-origin worldwide, and found that wild bird-origin H10N5 influenza viruses from China did not cluster together with human-origin H10N5 influenza viruses, while grouped together with LPAIV gene pools circulating in wild birds that derived from other Eurasian countries. Human-derived H10N5 virus is a novel reassortant, which frequently reassorted with wild bird-derived influenza viruses, and in turn, spillover into humans. Collectively, our results suggested that H10 subtype influenza viruses continuously pose threat to public health.
H10亚型禽流感病毒在全球野生和家养禽类中呈地方性流行。引人注目的是，它经常跨越物种屏障感染哺乳动物宿主。此前曾报告过人感染H10N3和H10N8的情况。最近，中国安徽省一名63岁女性死于H3N2和H10N5流感病毒的混合感染，这引起了广泛的公共卫生关注。在此，我们对全球鸟类和人类来源的H10N5流感病毒进行了进化动力学研究，发现来自中国的野生鸟类来源的H10N5流感病毒与人类来源的H10N5流感病毒没有聚集在一起，而是与来自其他欧亚国家的野生鸟类中传播的低致病性禽流感病毒基因库聚集在一起。人类来源的H10N5病毒是一种新型重组病毒，它经常与野生鸟类来源的流感病毒重组，进而传播给人类。总体而言，我们的结果表明，H10亚型流感病毒持续对公共卫生构成威胁。
