Plastic Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Front Endocrinol (Lausanne). 2024 Sep 24;15:1431984. doi: 10.3389/fendo.2024.1431984. eCollection 2024.
The relationship between sex steroid hormones and high-sensitivity C-reactive protein(hs-CRP) levels in American children and adolescents is understudied. This research will examine this association.
The study conducted a data analysis from the National Health and Nutrition Examination Survey (NHANES) 2015-2016, adjusting multiple linear regression models with R 4.2.2 and EmpowerStats. A total of 1,768 children and adolescents were surveyed. Data collection involved measurements of serum levels of testosterone, estradiol, sex hormone-binding globulin (SHBG) and hs-CRP.
With the increase in testosterone, a brief rise (β=0.082, =0.047) followed by an overall decline (β=-0.028, =0.023) in hs-CRP was observed in the Male Prepubertal population, while a continuous decline (β=-0.002, <0.05) was seen in the Male Pubertal group. A positive correlation (β=0.047, <0.05) was found between testosterone and hs-CRP in the Female Prepubertal population, whereas no significant association (β=0.002, >0.05) was detected in the Female Pubertal group. A significant inverse correlation was observed between estradiol and hs-CRP solely in the Female Pubertal group (β=-0.002, <0.05), while no association was found in other populations. An inverse relationship between SHBG and hs-CRP was consistently noted across all groups: Male Prepubertal, Male Pubertal, Female Prepubertal, and Female Pubertal.
The association between sex steroid hormones and high-sensitivity C-reactive protein (hs-CRP) levels among American children and adolescents is conditional and influenced by multiple factors.
性类固醇激素与美国儿童和青少年的高敏 C 反应蛋白（hs-CRP）水平之间的关系尚未得到充分研究。本研究将对此关联进行检验。
本研究对 2015-2016 年全国健康和营养调查（NHANES）的数据进行了分析，使用 R 4.2.2 和 EmpowerStats 调整了多元线性回归模型。共调查了 1768 名儿童和青少年。数据收集包括测量血清睾酮、雌二醇、性激素结合球蛋白（SHBG）和 hs-CRP 的水平。
在男性青春期前人群中，随着睾酮的增加，hs-CRP 先短暂升高（β=0.082，=0.047），然后总体下降（β=-0.028，=0.023），而在男性青春期人群中则持续下降（β=-0.002，<0.05）。在女性青春期前人群中，睾酮与 hs-CRP 呈正相关（β=0.047，<0.05），而在女性青春期人群中则无显著相关性（β=0.002，>0.05）。仅在女性青春期人群中观察到雌二醇与 hs-CRP 呈显著负相关（β=-0.002，<0.05），而在其他人群中则无相关性。SHBG 与 hs-CRP 之间呈负相关，这在所有人群中均一致：男性青春期前、男性青春期、女性青春期前和女性青春期。
性类固醇激素与美国儿童和青少年的高敏 C 反应蛋白（hs-CRP）水平之间的关联是有条件的，并受多种因素影响。
