Belinchón-Romero Isabel, Sánchez-Martínez Verónica, Ramos-Belinchón Clara, Ramos-Rincón José-Manuel
Department of Dermatology Dr. Balmis General University Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain.
Department of Clinical Medicine Miguel Hernández University Alicante Spain.
Health Sci Rep. 2024 Oct 8;7(10):e2286. doi: 10.1002/hsr2.2286. eCollection 2024 Oct.
Pyoderma gangrenosum (PG) is a neutrophilic inflammatory dermatosis that can be idiopathic or associated with other diseases. The aim was to analyze the epidemiological and clinical characteristics, temporal trends, risk factors for poor prognosis, and admission costs associated with PG in Spain.
We conducted a retrospective study, based on the Hospital Discharge Registry of the Spanish National Health System in Spain from 1999 to 2021.
Of 82,161,670 admissions during the study period, 4901 were for PG (hospitalization rate of 59.7/1,000,000 admissions). PG hospitalizations increased from 28.8/1,00,000 in 1999 to 91.9/1,000,000 in 2021. PG was a primary cause of admission in 60.5% of cases, and 58.4% of patients were women. The main PG-related comorbidities were inflammatory bowel disease (15.7%) and neoplasms (10%). There was a significant increase over the years in admissions for inflammatory bowel disease, monoclonal gammopathy of undetermined significance, and lymphoma, as well as an increase in diseases unrelated to PG, such as hypertension, diabetes, and chronic kidney disease. The hospital mortality rate was 5.6%. Death was associated with PG being a primary diagnosis, older age, leukemia, neoplasms, diabetes, and chronic kidney disease. The cost of treatment increased over the years and was higher in older people.
PG cases in the inpatient setting in Spain over the past 23 years make up a tiny proportion of all hospital admissions, although the rate of hospitalization for PG has increased in the last two decades.
坏疽性脓皮病（PG）是一种中性粒细胞性炎症性皮肤病，可为特发性或与其他疾病相关。目的是分析西班牙PG的流行病学和临床特征、时间趋势、预后不良的危险因素以及住院费用。
我们基于西班牙国家卫生系统1999年至2021年的医院出院登记进行了一项回顾性研究。
在研究期间的82161670例住院病例中，4901例为PG（住院率为59.7/1000000例住院）。PG住院率从1999年的28.8/100000增加到2021年的91.9/100000。PG是60.5%病例的主要入院原因，58.4%的患者为女性。与PG相关的主要合并症是炎症性肠病（15.7%）和肿瘤（10%）。多年来，炎症性肠病、意义未明的单克隆丙种球蛋白病和淋巴瘤的入院人数显著增加，与PG无关的疾病如高血压、糖尿病和慢性肾脏病的入院人数也有所增加。医院死亡率为5.6%。死亡与PG作为主要诊断、年龄较大、白血病、肿瘤、糖尿病和慢性肾脏病有关。治疗费用逐年增加，老年人的费用更高。
在过去23年中，西班牙住院患者中的PG病例占所有住院病例的比例极小，尽管在过去二十年中PG的住院率有所上升。
